市场上部分小儿氨酚黄那敏颗粒的质量调研

目的调研现市场上小儿氨酚黄那敏颗粒中对乙酰氨基酚和马来酸氯苯那敏的含量均匀度,考察该产品的质量情况。方法通过抽查现市场上8个小儿氨酚黄那敏颗粒产品,采用高效液相色谱法（HPLC）同时测定对乙酰氨基酚和马来酸氯苯那敏的含量均匀度。结果以对乙酰氨基酚和马来酸氯苯那敏的含量均匀度为衡量标准,有7个产品的对乙酰氨基酚的均匀度合格;有1个产品马来酸氯苯那敏的均匀度合格。结论所抽查的小儿氨酚黄那敏颗粒质量只有1个达到合格要求。

Quality research of Part Pediatric Paracetamol Atificial Cow-bezoar and Chlorphenamine Maleate Granules on the market

Objective To investigate the content uniformity of aceta minophen and chlorpheniramine maleate in Pediatric Paracetamol Atificial Cow-bezoar and Chlorphenamine Maleate Granules on the market.Methods Eight products of Pediatric Paracetamol Atificial Cow-bezoar and Chlorphenamine Maleate Granules on the market were sampled.The high performance liquid chromatography（HPLC） was used to measure the content uniformity of acetaminophen and chlorpheniramine maleate at the same time.Results Taking the content uniformity of acetaminophen and chlorpheniramine maleate as the measuring standards,the content uniformity of acetaminophen of 7 products was qualified and the content uniformity of chlorpheniramine maleate of 1 product was qualified.Conclusion Among the sampled products of Pediatric Paracetamol Atificial Cow-bezoar and Chlorphenamine Maleate Granules,only 1 product reaches the eligibility requirements.