布洛芬分散片的药效学研究

目的研究布洛芬分散片的药效学。方法应用布洛芬分散片探索对角叉胶所致大鼠足跖炎性肿胀的抗炎作用以及解热镇痛作用、内毒素致家兔发热的解热作用与醋酸致小鼠疼痛的镇痛效果。结果用布洛芬分散片低、中和高剂量组分别与空白组比较，动物关节肿胀程度明显减轻（P〈0．01），小鼠扭体次数显著减少（P〈0．01），家兔体温显著降低（JP〈0．01）。结论布洛芬分散片药效与片剂相同，可以作为一种新剂型开发。

Experimental study of pharmacodynamics of Ibuprofen Dispersible Tablets

Objective To study the pharmacodynamics of Ibuprofen Dispersible Tablets. Methods Ibuprofen Dispersible Tablets were used to explore the anti-inflammatory effect and the antipyretic and analgesic effect on the carrageenan-indueed rat footpad inflammatory swelling, the aritipyretic effect on the endotoxin-inducecl home rabbit fever and the analgesic effect on the acetate-induced mice pain. Results Compared with the control group, the joint swelling degree significantly relieved （P 〈 0.01）, the number of writhing times significantly reduced （P 〈 0.01） and the temperature of home rabbit significantly lowered （P 〈 0.01） in the low, medium and high dose ibuprofen dispersible tablet groups. Conclusion Ibuprofen Dispersible Tablets have the same pharmacodynamics with Ibuprofen Tablets and thus can be served as a new formulation.