阿维A药物应用于银屑病治疗的临床价值分析

目的探讨阿维A应用于银屑病治疗的临床应用价值。方法将2010年10月～2012年10月陕西省安康市汉滨区中医医院诊治的80例银屑病患者随机分成两组：对照组40例,采用窄谱中波紫外线（NB-UVB）全身照射治疗;实验组40例,采用NB-UVB＋阿维A治疗。观察和比较两组的临床疗效、银屑病皮损面积和严重程度指数（PASI）、皮肤病生活质量指数（DLQI）、炎症因子指标水平的改变情况。结果实验组较对照组的总有效率明显为高,差异有统计学意义（P〈0.05）;治疗后实验组的PASI、DLQI指标水平显著低于对照组（P〈0.05）;实验组患者治疗后的白介素-17（IL-17）、白介素-22（IL-22）、白介素-23（IL-23）指标水平均显著性小于对照组（P〈0.05）。结论阿维A辅助NB-UVB治疗银屑病能更好地控制皮损,调节炎症因子水平,提高患者的生活质量。

Clinical value analysis on treatment of psoriasis by Acitretin

Objective To investigate the clinical value of Acitretin for the treatment of psoriasis.Methods 80 cases of psoriasis patients admitted to Hanbin district hospital of traditional Chinese medicine of Ankang City in Shaanxi Province from October 2010 to October 2012 were randomly divided into two groups： 40 cases of control group were given narrow-band ultraviolet B（NB-UVB） irradiation treatment,and 40 cases of treatment group were also given Acitretin.The clinical efficacy,psoriasis area and severity index（PASI）,dermatology life quality index（DLQI）,and changes of interleukin-17（IL-17）,interleukin-22（IL-22）,interleukin-23（IL-23） level in two groups were observed and compared.Results The total efficiency rate in the treatment group was significantly higher than the control group（P 0.05）; the levels of PASI and DLQI in the treatment group after treatment were significantly lower than the control group（P 0.05）;the levels of IL-17,IL-22 and IL-23 in the treatment group after treatment were significantly lower than the control group（P 0.05）.Conclusion The clinical application of Acitretin for the treatment of psoriasis can significantly relieve the skin lesions,regulate inflammatory factor levels,and improve the patient＇s quality of life.