| 侯氏黑散对MCAO大鼠大脑皮质TGF-β_1 bFGF蛋白表达的影响 |
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| 引用本文： | 张秋霞,赵晖.侯氏黑散对MCAO大鼠大脑皮质TGF-β_1 bFGF蛋白表达的影响[J].辽宁中医杂志,2007,34(2):238-240. |
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| 作者姓名： | 张秋霞 赵晖 |
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| 作者单位： | 首都医科大学中医药学院,北京,100069 |
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| 基金项目： | 北京市教育委员会科技基金(KM2003100025099) |
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| 摘 要： | 目的:观察侯氏黑散对MCAO(大脑中动脉闭塞模型)大鼠大脑皮质TGF-β1、bFGF蛋白表达的影响。方法:采用线栓法复制大鼠大脑中动脉闭塞模型,利用免疫组化方法观察大鼠大脑中动脉闭塞模型皮质TGF-β1、bFGF蛋白表达的变化,通过给大鼠连续14天灌胃侯氏黑散13g.kg-1.d-1,观察其对TGF-β1、bFGF蛋白表达的影响。结果:侯氏黑散以促进TGF-β1阳性蛋白的表达,与模型组比较具有显著意义;侯氏黑散可以促进bFGF蛋白的表达,但与模型组相比,没有统计学的意义。结论:侯氏黑散治疗中风的机理可能是通过促进TGF-β1蛋白的表达,保护和修复缺血性脑损伤。
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| 关 键 词： | 侯氏黑散 大脑中动脉闭塞 转化生长因子 碱性成纤维细胞因子 |
| 文章编号： | 1000-1719(2007)02-0238-03 |
| 修稿时间： | 2006年5月23日 |
Effects of Houshihei San on Cerebral Focal TGF - β1 bFGF of MCAO Model in the Rat |
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| ZHAO Qiu-xia,ZHAO Hui.Effects of Houshihei San on Cerebral Focal TGF - β1 bFGF of MCAO Model in the Rat[J].Liaoning Journal of Traditional Chinese Medicine,2007,34(2):238-240. |
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| Authors: | ZHAO Qiu-xia ZHAO Hui |
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| Abstract: | Objective:To observe the effects of Houshihei San on cerebral focal TGF-β1、bFGF of MCAO model in the rat.Methods:MCAO model was replicated by string ligation and the change of TGF-β1,bFGF protein expression was detected by immunohistochemical ABC method.We observed the effects of Houshihei San on cerebral focal TGF-β1,bFGF protein expression after 14 days treatment(13g·kg-1·d-1).Result:In comparison with model group,Houshihei San can accerlate the TGF-β1 protein expression with statistical meaning and improve the bFGF protein expression without statistical meaning.Conclusion: The mechanism of Houshihei San treating stroke maybe is that it can accerlate the TGF-β1 protein expression in order to protect and repair the ischemia injury. |
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| Keywords: | Houshihei San middle cerebral artery occlusion transforming growth factory basic fibroblast growth factor |
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