长期使用苯二氮|类药物对老年人社区获得性|肺炎发展和预后的影响

目的 探讨长期使用苯二氮 类药物（benzodiazepines， BZDs）对老年社区获得性肺炎（community-acquired pneumonia， CAP）发展和预后的影响。方法 回顾性调查患者临床信息，根据是否长期使用BZDs分成观察组（84例）和对照组（103例），两组间一般资料比较，差异无统计学意义（P>0.05）。两组患者均进行常规的CAP治疗，比较两组患者的治疗效果、肺炎进展和预后情况。结果 两组治疗疗效比较，差异有统计学意义（P<0.05）；观察组临床肺部感染评分（CPIS）于治疗后7天起明显低于治疗前（P<0.05），晚于对照组；观察组病死率、转入危重监护病房（intensive care unit， ICU）比例、住院费用和天数均高于对照组，差异有统计学意义（P<0.05），不良反应比较，差异无统计学意义（P>0.05）。结论 长期使用BZDs的老年CAP患者抗感染效果劣于未使用者，且预后不佳，在老年CAP的治疗中，需慎用BZDs。

Influence of Long-term Use of Benzodiazepines on The Process and Prognosis in Elderly Community-acquired Pneumonia

Objective To study the influence of long-term use of BZDs on the process and prognosis of elderly CAP. Methods The clinical information of the patients was retrospectively analyzed. According to whether the long-term use of BZDs was divided into the observation group (84 cases) and the control group (103 cases), there was no significant difference between the two groups (P> 0.05). Two groups of patients were treated with conventional CAP, compared the two groups of patients with treatment, progress and prognosis of pneumonia. Results There was significant difference (P <0.05) in the therapeutic effect between the two groups; CPIS of the observation group after the treatment of 7d was significantly lower than that before treatment (P < 0.05), later than that of the control group. The mortality rate, ICU ratio, hospitalization cost and days of the observation group were significantly higher than those of the control group (P <0.05). Adverse reactions were no significant difference (P> 0.05) between the two groups. Conclusion Long-term using BZDs is not beneficial to the elderly CAP patients and worsen the prognosis situation. Therefore the clinical application of BZDs to elderly CAP patients should be made with cautiousness.