PTEN和MMP-2在膀胱移行细胞癌中的表达和相互关系

目的探讨PTEN和MMP-2在膀胱移行细胞癌中的表达和相互关系。方法应用SP免疫组织化学染色法检测52例膀胱移行细胞癌中PTEN和MMP-2的表达。结果PTEN和MMP-2在膀胱移行细胞癌中的阳性率分别为44%(23/52)和52%(27/52)。随着病理分级、临床分期的增高,PTEN的阳性率逐渐降低(P<0.01),MMP-2的阳性率逐渐增高(P<0.05)。在初发肿瘤和复发肿瘤中,PTEN的阳性率分别为56%(20/36)和19%(3/16)(P均<0.05),MMP-2的阳性率分别为47%(17/36)和63%(10/16)(P均>0.05)。在膀胱移行细胞癌中,PTEN和MMP-2的表达呈明显负相关(r=-0.39,P<0.01)。结论PTEN和MMP-2的阳性表达与膀胱移行细胞癌的分级、分期有关,PTEN的表达缺失和MMP-2的过表达在膀胱癌的发生、发展中起重要作用,并有助于判断预后。

Expression and relationship between PTEN and MMP-2 in bladder transitional cell carcinoma

Objective It is to approach the expression and relationship between phosphatase and tensin homology deleted on chromosome ten(PTEN) and matrix metalloproteinase-2(MMP-2) in bladder transitional cell carcinoma(BTCC) and their clinical significance.Methods The expressions of PTEN and MMP-2 in 52 cases with BTCC were detected by immunohistochemistry test(SP method).Results The positive rates of PTEN and MMP-2 were 44.23%(23/52) and 51.92%(27/52) respectively.With the pathological grade and the clinical stage of tumors being higher,the expression of PTEN was lower(P<0.05),and the expression of MMP-2 increased(P<0.05).In primary cancer and recurrent cancer,the positive rates of PTEN were 55.56%(20/36) and 18.75% respectively(P<0.05);the positive rates of MMP-2 were 47.22% and 62.5% respectively(P>0.05).The expression of PTEN was negatively correlated to the expression of MMP-2 in BTCC(r=-0.39,P<0.01).Conclusion The positive expression of PTEN and MMP-2 are significantly correlated to the tumor grade and clinical stage,the absent expression of PTEN and over expression of MMP-2 play an important role during the progress of carcinoma and are helpful for evaluating the prognosis of patients.