Longitudinal assessment of infant lung function following pregnancies complicated by prolonged and preterm rupture of the membranes |
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Authors: | P. Thompson A. Greenough K. H. Nicolaides |
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Affiliation: | (1) Department of Child Health, King's College Hospital, SE5 9RS London, UK;(2) Department of Obstetrics, King's College Hospital, SE5 9RS London, UK |
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Abstract: | Serial measurements of functional residual capacity (FRC) were made in 22 infants (median gestational age at delivery 32 weeks, range 25–40) during the first 2 years of life. All infants had been delivered from pregnancies complicated by prolonged and preterm rupture of the membranes (PPROM) of at least 1 week in duration. The onset of membrane rupture was at a median of 26 weeks (range 15–32) with a median duration of 5.5 weeks (range 1–21). The mean FRC at all postnatal ages studied: 25 ml/kg at 6 and 12 months and 24ml/kg at 18 and 24 months did not differ significantly from the control population (mean 24ml/kg). There was, however, a wider scatter of results in the study population: four infants born very preterm consistently had FRC results above the 95% confidence limits of the controls but only two infants had FRCs consistently below this range. These results suggest PPROM may not be an invariable association of abnormal antenatal lung growth. |
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Keywords: | Pulmonary hypoplasia Functional residual capacity Prematurity |
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