A clinicopathological and immunohistochemical study of central nervous system hemangiopericytomas |
| |
| Authors: | Challa Sundaram Shantveer G. Uppin Megha S. Uppin J. Sree Rekha Manas Kumar Panigrahi A.K. Purohit S. Rammurti |
| |
| Affiliation: | 1. Department of Anthropology, Delhi University, New Delhi, India;2. Department of Neurology, National Neurosciences Centre, Kolkata, India;3. Sickle Cell Institute Chhattisgarh, Raipur, India;1. Department of Pathology, Johns Hopkins University SOM, Baltimore, USA;2. Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University SOM, Baltimore, USA;3. The Johns Hopkins Bloomberg–Kimmel Institute for Cancer Immunotherapy, Baltimore, USA;4. Department of Dermatology, Johns Hopkins University SOM, Baltimore, USA;5. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA;6. Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA;7. Department of Surgery, Johns Hopkins University SOM, Baltimore, USA;8. Division of Biostatistics and Bioinformatics, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University SOM, Baltimore, USA;9. Melanoma and Immunotherapeutics Service, Division of Solid Tumor Oncology, Department of Medicine, Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, USA;10. Weill Cornell Medical College, New York, USA;11. Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, USA;12. Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA |
| |
| Abstract: | Hemangiopericytomas (HPC) of the central nervous system (CNS) are uncommon dural-based tumors that mimic meningiomas clinically and radiologically. Because there are few reports about these tumors from India, we aimed to study the clinico-pathological and immunohistochemical features of CNS HPC. During 2000 to 2008 all 23 patients diagnosed with HPC of CNS at our Institution were reviewed in the study (11 males and 12 females, mean age of 46 years). Clinical, radiological and histopathological features were reviewed. There were 14 patients with grade II and nine with grade III tumors. Immunohistochemistry with antibodies to epithelial membrane antigen (EMA), vimentin, S-100, CD34 and Ki-67 was done on routinely processed, paraffin-embedded sections of 20 tumors. All patients were EMA and S-100 negative, and vimentin positive. CD34 was positive in only five out of 20 patients. The mean Ki-67 labeling index was 4.25% in grade II tumors and 7.8% in grade III tumors. We concluded that HPC are distinct from meningiomas in morphology, immunohistochemistry and biologic behavior, although they resemble each other clinically and radiologically, HPCs need to be differentiated from meningiomas. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
