BIS监测下丙泊酚微量泵输注对胃肠癌手术患者血流动力学及应激反应的影响

目的 观察脑电双频指数(BIS)监测对胃肠癌患者术中丙泊酚微量泵输注的调控作用,并观察患者的血流动力学及应激反应改变.方法 选择安徽省滁州市中西医结合医院2017年1月至2019年12月收治的96例胃肠癌患者作为研究对象,采用随机数表法分为对照组和观察组,各48例.两组均行胃肠癌根治手术治疗,术中采用丙泊酚微量泵输注,...

Effect of propofol micropump infusion on hemodynamics and stress response in patients with gastric cancer surgery under BIS monitoring

Objective To observe the regulation effect of Bispectral Index(BIS)monitoring on intraoperative propofol micropump infusion in patients with gastrointestinal cancer,and observe the changes in the patients′hemodynamics and stress response.Methods A total of 96 patients with gastric cancer treated in the Integrated Traditional Chinese and Western Medicine Hospital of Chuzhou City from January 2017 to December 2019 were selected as the research subjects.According to the random number table method,they were divided into a control group and an observation group,each with 48 cases.Both groups underwent radical resection of gastric cancer and were given propofol micropump infusion during the operation.In the control group the amount of propofol was adjusted manually during the operation,and in the observation group it was monitored by BIS during the operation.The amount of propofol was adjusted according to the BIS value.The hemodynamicsmean arterial pressure(MAP),heart rate(HR)]and stress responsethyroxine(T4),cortisol(Cor)]of the two groups were detected and compared before induction of anesthesia(T₀),30 minutes from the start of surgery(T₁),and at the end of surgery(T₂);the adverse reactions during the medication of the two groups were recorded.Results The MAP and HR levels of the two groups at T₁ and T₂ were lower than those at T₀,and the MAP and HR at T₂ were lower than those at T₁;the MAP and HR of the observation group at T₁ and T₂ were lower than those of the control group;there were significant differences between the two groups and among different time points(P<0.05).The T4 and Cor of the two groups at T₁ and T₂ were higher than those at T₀,and the T4 and Cor at T₂ were higher than those at T₁;the T4 and Cor of the observation group at T₁ and T₂ were lower than those of the control group;there were significant differences between the two groups and among different time points(P<0.05).The incidence of adverse reactions in the observation group was slightly lower than that in the control group,but there was no significant difference(P>0.05).Conclusion BIS monitoring has high application value in intraoperative anesthesia monitoring for patients with gastric cancer surgery,which can control the hemodynamics of patients during the whole operation and reduce their stress response,and is worthy of clinical promotion and application.