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Ischemic stroke in an adult with glycogen storage disease type I
Authors:J.M. Goulart  J.Y. Yoo  K.F. Kirchoff-Torres  B.N. Delman  S. Tuhrim
Affiliation:1. Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;2. Department of Neurology, Kurashiki Heisei Hospital, Okayama, Japan;3. Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan;1. Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy;2. Department of Cardiovascular Diseases, Papardo – Piemonte Hospital, Messina, Italy;1. Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan;2. Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiwan;3. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;4. Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;5. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
Abstract:Glycogen Storage Disease Type I (GSD-I) is a metabolic disorder characterized by deficiency of glucose-6-phosphatase resulting in ineffective glycogen metabolism to glucose. These patients frequently have hyperlipidemia, among many other metabolic derangements. There is no consensus regarding the risk of developing atherosclerosis. We report an adult male with GSD-I who presented with cerebral infarction and a history of prior ischemic stroke and multiple coronary stent placements. We suggest that patients with GSD-I do have an increased risk of atherosclerosis and its complications and predict that these complications will be seen more frequently since patients with GSD-I are living longer as a result of better treatment.
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