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Hypertrophic pachymeningitis and cerebral venous sinus thrombosis in inflammatory bowel disease
Authors:Zongqi Xia  Alice Chen-Plotkin  Jeremy D. Schmahmann
Affiliation:1. Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, USA;2. Department of Neurology and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA;3. Department of Neurology, Massachusetts General Hospital, Massachusetts, USA;4. Center for Neurologic Diseases, Brigham and Women’s Hospital, 77 Avenue Louis Pasteur, NRB 168A, Boston, Massachusetts 02115, USA;1. First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland;2. Department of Neurology, Military Institute of Aviation Medicine, Warsaw, Poland;1. Tulane University School of Medicine, New Orleans, Louisiana;2. Mayo Clinic College of Medicine, Rochester, Minnesota;1. Department of Biotechnology, Sri Venkateswara University, Tirupati 517502, A.P., India;2. Department of Zoology, Sri Venkateswara University, Tirupati 517502, A.P., India;1. Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, Zhejiang Province, People''s Republic of China;2. Department of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, Zhejiang Province, People''s Republic of China
Abstract:Hypertrophic pachymeningitis is rarely observed in inflammatory bowel disease. We report a woman with ulcerative colitis whose biopsy-confirmed hypertrophic pachymeningitis was complicated by cerebral venous sinus thrombosis and intracranial hypertension and required ventriculostomy and steroid therapy. This report highlights the challenges of the diagnosis and management of hypertrophic pachymeningitis from an unusual primary cause.
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