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An elderly female patient with tardive oromandibular dystonia after prolonged use of the histamine analog betahistine
Authors:G. De Riu  M.P. Sanna  P.L. De Riu
Affiliation:1. Department of Psychiatry, Meharry Medical College, Nashville, TN, United States;2. Department of Psychiatry and Behavioral Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States;3. Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA, United States;4. Department of Medical Pathology and Laboratory Medicine, University of California, Davis Health Systems, Sacramento, CA, United States;5. Psychiatric Services, California Clinical Trials, Glendale, CA, United States;6. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States;7. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States;8. Department of Psychiatry, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States;9. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, United States;10. Department of Psychology, University of California, Los Angeles, CA, United States
Abstract:Tardive oromandibular dystonia (OMD) is iatrogenic in origin and is characterised by orofacial and lingual stereotypes more frequently than the idiopathic form of OMD Tardive OMD is often associated with anti-dopaminergic treatment involving drugs such as anti-psychotics, anti-emetics, and anti-vertigo agents, although the syndrome can also be triggered by anti-epileptic or anti-depressant drugs that do not have anti-dopaminergic properties. We report an elderly female patient with OMD after prolonged, self-administered treatment with betahistine dihydrochloride, a histamine analogue.
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