Assessment of glioma proliferation using imaging modalities |
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| Authors: | George A Alexiou Spyridon Tsiouris Athanasios P Kyritsis Maria I Argyropoulou Spyridon Voulgaris Andreas D Fotopoulos |
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| Institution: | 1. Department of Neurosurgery, Chinese Medicine Hospital of Guangdong Province, Guangzhou, China;2. The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China;3. International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, University Hospital, Uppsala University, S-75185 Uppsala, Sweden;1. Department of Medical Imaging, Affiliated Hospital of Nantong University, NO. 20 Xisi Road, Nantong 226001, Jiangsu, People''s Republic of China;2. Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People''s Republic of China |
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| Abstract: | The assessment of glioma proliferation rate is important to predict tumor behavior, response to therapy and prognosis. Various methods, largely involving immunohistological markers in tissue samples, have been proposed to this aim; however, they all require tissue removal through a biopsy or during a surgical procedure. Consequently, non-invasive imaging modalities that could reliably assess the proliferative potential of intracranial space-occupying lesions in vivo would be of obvious significance. In the present study we review the contribution of MRI, positron emission tomography and single-photon emission CT for the assessment of the proliferative potential of gliomas. |
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