化学发光法检测非小细胞肺癌患者血清雌激素和血管内皮生长因子水平及其临床意义

目的采取化学发光法测定非小细胞肺癌患者血清雌激素和血管内皮生长因子水平,分析其临床意义。方法筛选2016年1月-2017年11月在广东省湛江市第四人民医院就诊的非小细胞肺癌患者50例作为非小细胞肺癌组,另选择同期行体检健康者40例为对照组。采取全自动化学发光测定仪测定并比较2组血清雌激素和血管内皮生长因子水平,分析非小细胞肺癌患者血清雌激素和血管内皮生长因子水平与患者临床病理特征的关系。随访2年,比较死亡患者与存活患者入院时血清雌激素和血管内皮生长因子水平。结果非小细胞肺癌组患者血清雌激素和血管内皮生长因子水平均显著高于对照组(P<0.01)。非小细胞肺癌患者血清雌激素和血管内皮生长因子水平与患者的性别、年龄、吸烟史、病理类型、肿瘤直径无关(P>0.05),与非小细胞肺癌的分化程度、TNM分期、淋巴结转移有关(P<0.05)。随访2年,死亡14例,存活36例,死亡患者入院时血清雌激素和血管内皮生长因子水平均显著高于存活组(P<0.01)。结论非小细胞肺癌患者血清雌激素和血管内皮生长因子水平显著升高,与肺癌临床病理特征和预后相关。

Chemiluminescence detection of serum estrogen and vascular endothelial growth factor levels in patients with non-small cell lung cancer and its clinical significance

Objective To adopt chemiluminescence method to determine serum estrogen and vascular endothelial growth factor levels in patients with non-small cell lung cancer,and to analyze their clinical significance.Methods 50 patients with non-small cell lung cancer who were treated at the Fourth People’s Hospital of Zhanjiang,Guangdong Province from January 2016 to November 2017 were selected as the non-small cell lung cancer group,and 40 healthy people who underwent physical examination during the same period were selected as the control group.An automatic chemiluminescence analyzer was used to measure and compare the serum estrogen and vascular endothelial growth factor levels of the two groups,and to analyze the levels of serum estrogen and vascular endothelial growth factor of in patients with non-small cell lung cancer and the clinical pathological characteristics of the patients.Followed up for 2 years,the levels of serum estrogen and vascular endothelial growth factor of the dead and surviving patients were compared.Results The serum estrogen and vascular endothelial growth factor levels in the non-small cell lung cancer group were significantly higher than those in the control group(P<0.01).The levels of serum estrogen and vascular endothelial growth factor in the non-small cell lung cancer group were significantly higher than those in the control group(P<0.01).The levels of serum estrogen and vascular endothelial growth factor in the non-small cell lung cancer group were not related to the patient’s gender,age,smoking history,pathological type,and tumor diameter(P>0.05),but were related to the degree of differentiation,TNM staging,and lymph nodes transfer related related(P<0.05).After 2 years of follow-up,14 cases died and 36 cases survived,serum estrogen and vascular endothelial growth factor levels of the dead patients were significantly higher than those in the survival group(P<0.01).Conclusion The levels of serum estrogen and vascular endothelial growth factor in patients with non-small cell lung cancer are significantly increased,which are related to the clinicopathological characteristics and prognosis of lung cancer.