The Wada memory test and prediction of outcome after anterior temporal lobectomy |
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| Authors: | Hsiang-Yu Yu Yang-Hsin Shih Tung-Ping Su Ian-Kai Shan Chun-Hin Yiu Yung-Yang Lin Shang-Yeong Kwan Chien Chen Der-Jen Yen |
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| Institution: | 1. Department of Neurology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan;2. Department of Neurosurgery, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan;3. Department of Psychiatry, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan;1. Selcuk University, Department of Radiation Oncology, Konya, Turkey;2. Selcuk University, Department of Nephrology, Konya, Turkey;3. Konya Training and Research Hospital, Department of Radiation Oncology, Konya, Turkey;4. Selcuk University, Department of Ear, Nose and Throat, Konya, Turkey;5. Selcuk University, Department of Medical Oncology, Konya, Turkey;1. Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;2. Research Center for Biomedical Technologies & Robotics (RCBTR), Tehran University of Medical Sciences, Tehran, Iran;3. Clinical Nanomedicine Laboratory, ENT – Head & Neck Research Center, Hazrate Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran;4. Department of Engineering, Shahed University, Tehran, Iran;5. Department of Audiology, Rehabilitation Research Center, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran;6. Rehabilitation Research Center, Iran University of Medical Sciences, Tehran, Iran;1. Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, 2 Tampa General Circle, USF Health, 7th Floor, Tampa, FL 33606, USA;2. Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, 3515 East Fletcher Avenue, Tampa, FL 33613, USA;3. Department of Neurology, Morsani College of Medicine, University of South Florida, 2 Tampa General Circle, USF Health, 6th Floor, Tampa, FL 33606, USA;1. Department of Pediatrics, Wayne State University and Children''s Hospital of Michigan, Detroit, Michigan;2. Department of Neurology, Wayne State University, Detroit, Michigan;3. Division of Pediatric Neurology, Nemours A.I. duPont Hospital for Children, Wilmington, Delaware;4. Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania |
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| Abstract: | We reviewed the records of 77 Chinese-speaking adult patients to investigate the relationship between the Wada memory test and outcomes after anterior temporal lobectomy (ATL). The ipsilateral memory scores, contralateral memory scores and Wada asymmetry index (WAI) were calculated to evaluate their relationships with seizure and cognitive outcomes. The seizure outcomes did not correlate with the unilateral memory scores or the WAI. Patients who had a smaller WAI tended to have a post-operative decline in verbal intelligence quotient (VIQ) (odds ratio: 13.54, 95% confidence interval: 1.17–156.11, p = 0.037). The seven patients who failed the Wada memory test after ipsilateral injection had a higher percentage of VIQ deterioration than the 70 who passed (p = 0.039). However, no patient displayed global amnesia after surgery. The Wada memory test was a predictor for post-operative VIQ changes in our study. Patients who failed the Wada memory test still benefitted from the ATL and showed good seizure outcomes. |
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