河北省保定地区淋病双球菌的耐药性测定

目的：了解本地区淋病双球菌耐药性，为临床合理用药提供参考依据。方法：采集性病门诊疑似淋病患男性尿道、女性尿道和宫颈分泌物，接种T-M淋球菌培养基，培养分离淋球菌。将分离菌株做初步鉴定和生化鉴定，确认为淋病双球菌，做耐药性测定。采用世界卫生组织(WHO)推荐的改良Kirby-Bamer(K-B)氏法测定耐药性，按《美国NCCLS药敏试验纸片扩散法法规》标准判读结果。结果：28株淋病双球菌的耐药率青霉素G为28．57％、四环素为57．14％、头孢三嗪为14．29％、壮观霉素为0％、氟哌酸为75．00％。并出现了多重耐药菌株，其中对3种抗生素耐药的占28．57(8／28)。结论：推荐壮观霉素和头孢三嗪为本地区治疗淋病的首选药物。

Analysis on antibiotic - resistance of Neisseria Gonorrhoeae in Baoding region, Hebei province

Purpose To understand the antibiotic - resistance of Neisseria Gonorrhoeae, so as to provide proofs of clinical - selected antibioticsand appropriate therapy. Methods The data collected from suspectgonorrhea patients(urethra of male and female, cervical discharge of female) were de- tected for N. Gonorrhoeae with T - M Gonorrhoeae Culture Medium. Isolated strains were as primary identification and biochemical identification.The antibiotic - resistance of Neisseria of gonor- rhoeaewere identificated by Kirby - Burner(K - B) recommended by WHO. The results were detected by NCCLS. Results Of the 28 gonococcal isolates, resistant rates to penicillin, tetracycline,ceftri- axone, spectinomycin, norfloxacin were 28. 57%, 57. 14%, 14. 29%, 0%and 75. 00%, respectively. Moreover, many of the isolates showed cross resistance, 28. 57% (8/28)of the isolates were resistant to three kinds of antibiotics simultaneously. Conclusion Spectinomycin and ceftriaxone are recom- mended as first - choice antibiotics to treat gonorrhea.