脾胃湿热证胃病患者胃黏膜细胞凋亡基因相关蛋白的表达

目的]探讨脾胃湿热证胃病患者胃黏膜细胞凋亡基因相关蛋白的表达。方法]选取脾胃湿热证胃病患者70例,检测胃黏膜Fas、p53、增殖细胞核抗原(PCNA)、Bcl-2凋亡基因相关蛋白。并与70例脾胃虚寒证胃病患者进行对照。结果]脾胃湿热证以糜烂性胃炎多见(58.6%),而脾胃虚寒证以萎缩性胃炎多见(22.9%)。脾胃湿热证患者Fas、p53表达明显高于脾胃虚寒证患者,阳性率分别为74.3%、75.7%和55.7%、64.3%(P<0.05),而PCNA、Bcl-2表达则与脾胃虚寒证患者差异无统计学意义。结论]脾胃湿热证胃病患者胃黏膜细胞有促凋亡基因相关蛋白的过度表达。

Expression of apoptosis related proteins in gastric mucosa of gastric disease patients with the spleen-stomach damp-heat syndrome

Objective] To study the expression of apoptosis related proteins in gastric mucosa of gastric disease patients with the syndrome of damp-heat in the spleen and the stomach.Methods]The apoptosis related proteins,including Fas,p53,PCNA and Bcl-2,in seventy gastric disease patients with the syndrome of damp-heat in the spleen and the stomach were measured and compared with those in seventy gastric disease patients with the syndrome of spleen-yang insufficiency.Results] The syndrome of damp-heat in the spleen and the stomach was very common in patients with erosive gastritis(58.6%).The syndrome of spleen-yang insufficiency accounted 22.9% in patients with atrophic gastritis.The positive rate of the expression of Fas and p53 in the gastric disease patients with the syndrome of damp-heat in the spleen and the stomach was 74.3% and 75.1% respectively,higher than those in the gastric disease patients with the syndrome of spleen-yang insufficiency,but the expression of PCNA and Bcl-2 had no significant difference between the gastric disease patients with the syndrome of damp-heat in the spleen and the stomach and the patients with the syndrome of spleen-yang insufficiency.Conclusion ]There exists overespression of p53 or Fas in gastric disease patients with the syndrome of damp-heat in the spleen and the stomach.