| 高碘和低碘甲状腺肿小鼠血清T3,T4和TSH的变化比较 |
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| 引用本文： | 尹桂山,朱惠民.高碘和低碘甲状腺肿小鼠血清T3,T4和TSH的变化比较[J].河北医科大学学报,1989,10(1):14-16. |
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| 作者姓名： | 尹桂山 朱惠民 |
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| 作者单位： | 河北医学院生化教研室(尹桂山，王桂香，杜秀全)，河北医学院环境卫生学教研室(朱惠民) |
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| 摘 要： | 本研究观察了给高碘和低碘饲料20～360天中6组小鼠血清T_3、T_4和TSH的变化,并对二者进行了比较。发现高碘动物组血清T_4升高,低碘组T_3升高,T_4 降低,低碘组实验中期TSH升高。结果提示,高碘甲状腺肿的发病机理与低碘甲状腺肿不同。
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| 关 键 词： | 甲状腺素 三碘甲状腺原氨酸 促甲状腺激素 甲状腺肿 |
THE COMPARISON OF THE CHANGES OF SERUM LEVEL OF T_3, T_4 AND TSH IN MICE WITH IODINE-EXCESS AND IODINE-DEFICIENT GOITER |
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| Yin Guishan Wang Guixiana Du Xuiquan.THE COMPARISON OF THE CHANGES OF SERUM LEVEL OF T_3, T_4 AND TSH IN MICE WITH IODINE-EXCESS AND IODINE-DEFICIENT GOITER[J].Journal of Hebei Medical University,1989,10(1):14-16. |
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| Authors: | Yin Guishan Wang Guixiana Du Xuiquan |
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| Institution: | Yin Guishan Wang Guixiana Du Xuiquan (Department of Biochemistry) Zhu Huimin (Department of Environmental Health) |
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| Abstract: | The changes of serum levels of T_3, T_4 and TSH in mice fed with iodine-excess and iodine-deficent diets were compared. Higher serum T_4 concentrationwas observed in iodine-excess group, whereas in iodine-deficent group theconcentraton of it was decreased, but T_3 increased. The level of TSH wasincreased during the mid-stage of experiment in iodine-deficient group.According to these results the authors suggest that the pathogenetic mechanism of iodine-excess goiter is different from that of the iodine-deficentgoiter. |
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| Keywords: | thyroxine(T_4) triiodothyronine(T_3) thyrotrophin(TSH) goiter |
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