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Autoantibody status and histological variables influence biochemical response to treatment and long‐term outcomes in Japanese patients with primary biliary cirrhosis
Authors:Minoru Nakamura  Hisayoshi Kondo  Atsushi Tanaka  Atsumasa Komori  Masahiro Ito  Kazuhide Yamamoto  Hiromasa Ohira  Mikio Zeniya  Etsuko Hashimoto  Masao Honda  Shuichi Kaneko  Yoshiyuki Ueno  Kentaro Kikuchi  Shinji Shimoda  Kenichi Harada  Kuniaki Arai  Yasuhiro Miyake  Masanori Abe  Makiko Taniai  Toshiji Saibara  Shotaro Sakisaka  Hajime Takikawa  Morikazu Onji  Hirohito Tsubouchi  Yasuni Nakanuma  Hiromi Ishibashi
Affiliation:1. Clinical Research Center in National Hospital Organization (NHO) Nagasaki Medical Center and Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Japan;2. Headquaters of gp210 working in Intractable Hepatobiliary Disease Study Group supported by the Ministry of Health, Labor and Welfare of Japan, Tokyo, Japan;3. Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;4. Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan;5. Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;6. Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan;7. Division of Gastroenterology and Hepatology, Tokyo Jikei University School of Medicine, Tokyo, Japan;8. Department of Medicine and Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan;9. Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan;10. Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan;11. Department of Internal Medicine, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan;12. Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;13. Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan;14. Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Matsuyama, Japan;15. Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan;16. Department of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan;17. Department of Digestive and Lifestyle‐related Disease, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan
Abstract:
Keywords:anticentromere antibody  anti‐gp210 antibody  bezafibrate  biochemical response to treatment  histological staging and grading for primary biliary cirrhosis  ursodeoxycholic acid
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