玉米肽对酒精性肝损伤大鼠的作用研究

目的 探讨玉米对于酒精性肝损伤大鼠的保护作用.方法 SPF级雌性大鼠,随机分为5组:对照组、模型组和玉米肽干预组(3组剂量分别为0.225、0.45、0.9g/kg),连续4周以乙醇6g/(kg·d)造成大鼠酒精性肝损伤模型,并给予玉米肽干预,测定各组体重变化和血清转氨酶、病理、抗氧化酶等指标,分析各组间的差异.结果 摄入酒精后大鼠一般生活状况和血清转氨酶指标发生均产生了明显改变(P<0.05),玉米肽干预对饮酒大鼠的一般状况有一定的改善,可以逆转饮酒导致大鼠的转氨酶水平升高,改善肝组织病理学异常,提高血清超氧化物歧化酶活性并降低丙二醛水平(P<0.05),但是体重、谷胱甘肽过氧化物酶、肝乙醇脱氢酶等没有观察到明显的改变.结论 玉米肽对大鼠酒精性肝损伤具有一定的保护作用,可能与改善机体氧化应激有关.

Effect of Corn Peptides on Alcoholic Liver Injury of Rats

Objective To investigate the effects of corn peptides on alcoholic liver injury in female rats. Methods SD female rats were randomly divided into 5 groups: control group, model group, and three corn peptides groups(0.225, 0.45, 0.9g/kg). All rats except in control group received intragastrical administration of alcohol of 6 g/kg body weight per day to induce liver injury for four weeks continuously, which was then evaluated by serum markers and hisopathological examination. Results The general conditions and serum transaminase of rats produced a significant change after alcohol intake (P<0.05). Corn peptides intervention after drinking could reverse the increased level of serum aminotransferase and alleviated the hepatic histological damage induced by alcohol. It also increased the serum superoxide dismutase activity and decrease malondialdehyde level (P<0.05). But there was no obvious change observed in the contents of body weight and alcohol dehydrogenase. Conclusion Corn peptides have a significant protective effect on alcoholic liver injury in rats, which is possibly associated with enhancing anti-oxidation level.