氨氯地平与阿折地平治疗原发性高血压疗效的比较

目的探讨并比较氨氯地平及阿折地平对轻中度原发性高血压患者的治疗效果。方法入选轻中度高血压患者55名,随机双盲分为两组:氨氯地平组和阿折地平组,两组患者均经过2周的药物洗脱期,分别给予8周的氨氯地平(5～10mg/d)或阿折地平(8～16mg/d)治疗,在治疗前后进行动态血压监测,比较两组患者治疗前后组内及组间血压的差异,并计算其谷峰比值(T/P)和平滑指数(SI)。结果治疗8周后:(1)与服药前比较,氨氯地平组SBP和DBP分别下降(16.1±11.3)mm Hg和(11.9±6.4)mm Hg,差异均有统计学意义(均为P<0.05);阿折地平组SBP和DBP均显著下降(21.2±11.9mm Hg)和(15.4±7.4mm Hg,均为P<0.01)。氨氯地平、阿折地平两组间比较,差异无统计学意义(均为P>0.05)。(2)T/P:氨氯地平组用药后SBP、DBP的T/P分别为63%和92%,阿折地平组SBP与DBP的T/P分别为60%和61%。(3)SI:氨氯地平组分别为SBP(1.27±0.24),DBP(1.33±0.20)。阿折地平组分别为SBP(1.29±0.21),DBP(1.24±0.19)。氨氯地平、阿折地平两组之间进行比较,差异无统计学意义(均为P>0.05)。结论氨氯地平、阿折地平对轻中度原发性高血压患者治疗效果好,两药T/P均符合美国FDA对每天服药1次的抗高血压药T/P>50%的要求。SBP及DBPSI均大于1。

Antihypertensive comparison of amlodipme and azelnidipine for mild to moderate essential hypertension

Objective To compare the antihypertensive effect of amlodipine and azelnidipine for mild to moderate essential hypertension.Methods A total of 55 patients with mild to moderate essential hypertension were randomly divided into amlodipine group(n =28) and azelnidine group(n =27).After drug wash-oul period(2 weeks),amlodipine(5 mg to 10 mg once daily) or azelnidine(8 mg to 16 mg once daily) were given for 8 weeks,24-hour ambulatory blood pressure monitoring(ABPM) was performed before and after treatment,and T...