2008至2012年复旦大学附属中山医院就诊人群血脂水平回顾调查

目的分析2008至2012年特定人群血脂水平的变化情况，为血脂异常的诊治提供参考。方法选取2008年1月至2012年12月初次检测血清总胆固醇（TC）或甘油三酯（TG）的就诊人群，排除同年多次重复检测的结果后获得数据1810982例（TC为904373例、TG为906609例）。按就诊原因（分为住院、门诊、体检3组）、年龄、性别分别分组，统计分析血脂水平差异。结果5年内TC、TG水平均呈明显上升趋势。门诊组血脂水平最高，5年内Tc水平无明显变化，TG水平总体呈逐渐下降趋势；体检组居中，Tc水平2012年较2008年增长6．71％，TG水平5年内明显上升；住院组最低，其Tc水平2009年较2008年增长明显，2009年后无明显变化，TG水平2008至2012年明显上升。全体人群中TC≥6．22mmoL、TG≥2．26mmol／L的人数比例均高于体检人群；5年内TC≥6．22mmol／L、TG≥2．26mmoL的人数比例在2组人群中均呈上升趋势。男、女性TC、TG水平在多数年龄组中均有明显增高，21～40岁增高明显。女性TC水平除21～50岁外，其余年龄组均高于男性；男性50岁前TC水平随年龄增长而增高，70岁后随年龄增长而降低；女性70岁前TC水平随年龄增长明显。60岁前男性TG水平高于女性，60岁后女性高于男性。男性50岁前TG水平随年龄升高，50岁后逐渐降低；女性TG水平在70岁前随年龄变化而增长，70岁后呈下降趋势。结论2008至2012年血脂水平呈上升趋势，血脂异常率升高且有年轻化趋势，提示应重视中青年人血脂水平的管理。

Retrospective investigation on serum lipid levels of the patients in Zhongshan Hospital,Fudan University,from 2008 to 2012

Objective To study the changes of serum lipid levels among the patients from 2008 to 2012,and to provide references for the diagnosis and treatment of dyslipidemia. Methods Statistical methods were used to analyze 1 810 982 samples from the patients being detected for total cholesterol （TC） or triglyceride （TG） levels for the first time during January 2008-December 2012 （TC： 904 373 cases and TG： 906 609 cases）. The differences were analyzed statistically, according to the causes of treatment （ inpatient group, outpatient group and healthy examination group）, age and sex. Results There was an obvious increasing trend in both TC and TG levels during the 5 years. The serum lipid levels of outpatient group were higher than those of inpatient group and healthy examination group. TC levels of outpatient group had no statistical difference in the 5 years, and TG levels decreased. TC levels in 2012 had a growth of 6.71% compared with those in 2008 in healthy examination group, and TG levels also increased significantly in the 5 years. The serum lipid levels of inpatient group were the lowest. Compared with those in 2008, TC levels of inpatient group increased in 2009, and then had no difference in the later years, while TG levels kept increasing from 2008 to 2012. The percentage of subjects with TC 〉6.22 mmol/L and TG i〉 2.26 mmol/L was higher in the entire subjects than in healthy examination group. The percentages of subjects with TC〉 6.22 mmoL/L and TG〉 2.26 mmol/L increased in both the 2 groups during the 5 years. TC and TG levels of males and females went up in the most age groups, especially in the age group of 21- 40. TC levels were higher in males than those in females only among 21-50 age groups. TC levels in males increased with age before 50, and decreased with age after 70, while TC levels in females increased with age before 70. TG levels were higher in males than in females before 60, and were lower after 60. TG levels of males went up with age before 50, and then went down after 50, while TG levels of females went uo before 70. and then went downafter 70. Conclusions There is an increasing trend in serum lipid levels during 2008-2012. The prevalence of dyslipidemia among young population shows ascending trend, which should pay more attention to the management of serum lipid levels in young and middle-aged population.