Wilms tumor presenting with abdominal pain: A special subgroup of patients |
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Authors: | Andrew M Davidoff MD Alexander D Soutter MD Stephen J Shochat MD |
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Institution: | (1) From the Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania;(2) Dept. of Surgery, St. Jude Children's Research Hospital, 332 N. Lauderdale St., 38105-2794 Memphis, TN |
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Abstract: | Background: Although significant progress has been made in the management of children with Wilms tumor, two major controversies still exist: the extent of radiographic evaluation necessary before surgery and the role of preoperative chemotherapy. This study sought to determine whether patients with Wilms tumor who presented with abdominal pain defined a special subset of patients who might require a more extensive preoperative work-up and neoadjuvant chemotherapy.
Methods: From 1970 to 1995, 250 children were treated for Wilms tumor at a single pediatric institution. A retrospective chart review determined presenting signs and symptoms for each patient.
Results: Thirty-four (14%) patients (mean age 5.5 years) sought medical attention with a chief complaint of abdominal pain. The stage distribution for these patients tended to be higher and was significantly different (P<.001, x2-analysis) from those presenting without pain. Four (14%) of 29 patients with tumor available for analysis were found to have anaplastic histology.
Conclusion: These data suggest that patients with Wilms tumor who present with abdominal pain represent a special subgroup that tends to be older and has an increased incidence of tumor rupture, anaplasia, and higher stage. These patients may benefit from a more extensive preoperative evaluation and consideration of neoadjuvant chemotherapy.Presented at the 50th Annual Cancer Symposium of The Society of Surgical Oncology, Chicago, Illinois, March 20–23, 1997. |
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Keywords: | Wilms tumor Abdominal pain Presentation |
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