单向活瓣及肺动脉注入前列腺素E1(PGE1)治疗室缺合并肺动脉高压

目的探讨基层医院室缺合并重度肺动脉高压(PH)的外科治疗方法。方法 41例室缺合并肺动脉高压患者采用单向活瓣补片修补室间隔缺损,同时肺动脉内留置导管泵入前列腺素E1(PGE1);术后超声心动图动态监测分流情况,并比较术前术后肺动脉压(PAP)及血气分析指标变化。结果 41例患者无1例死亡,术后2个月内单向活瓣关闭、分流消失;术后PAP明显下降,血气分析指标明显改善。结论单向活瓣补片及肺动脉置管泵入前列腺素E1(PGE1)能有效提高基层医院室缺合并肺动脉高压的治疗效果,增加围手术期安全性。

ONE-WAY VALVE AND THE PULMONARY ARTERY INJECTION OF PROSTAGLANDIN E1 (PGE1) TREATMENT OF VENTRICULAR SEPTAL DEFECT WITH PULMONARY HYPERTENSION

Objective To evaluate the effective of surgical treatments on congenital heart defects with severe pulmonary hypertension （PH） in primary hospital. Methods 41 cases of ventricular septal defect with pulmonary hy- pertension were treated with one - way valved patch repair of ventricular septal defect, and pulmonary artery catheter infusion of prostaglandin E1 （ PGE1 ） ; postoperative echocardiography dynamic monitoring of diversion, and to com- pare before and after operation pulmonary artery pressure （PAP） and arterial blood gas analysis were observed. Re- suits No one cases of 41 patients died within 2 months after a one - way valve closed, shunt disappeared; postopera- tive PAP decreased significantly improved blood gas analysis. Conclusion One - way valved patch and the pulmona- ry artery catheter infusion of prostaglandin El （ PGE1 ） can effectively improve the primary hospital ventricular septal defect with pulmonary hypertension treatment, an increase of perioperative safety.