| Effect of Cornus officinalis glycoside on adjuvant-induced arthritis in rats |
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| 引用本文： | Shi Ping ZHAO,Jian Min LI,Gui Xiang FU and Yong ZHOU Institute of Clinical Medical Sciences,China-Japan Friendship Hospital,Beijing,P. R. China Beijing University of Traditional Chinese Medicine,Beijing,P. R. China. Effect of Cornus officinalis glycoside on adjuvant-induced arthritis in rats[J]. 中华微生物学和免疫学杂志(英文版), 2006, 0(3) |
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| 作者姓名： | Shi Ping ZHAO Jian Min LI Gui Xiang FU and Yong ZHOU Institute of Clinical Medical Sciences China-Japan Friendship Hospital Beijing P. R. China Beijing University of Traditional Chinese Medicine Beijing P. R. China |
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| 作者单位： | Shi Ping ZHAO，Jian Min LI，Gui Xiang FU and Yong ZHOU Institute of Clinical Medical Sciences，China-Japan Friendship Hospital，Beijing，P. R. China Beijing University of Traditional Chinese Medicine，Beijing，P. R. China |
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| 摘 要： | The aim of this study was to explore the effect of Cornus officinalis glucosides (COG) on adjuvant-induced arthritis in rats and its mechanism. Seventy-two rats were divided into six groups of normal, model, Dexasone (0.125 mg/kg), high-dose COG (240 mg/kg), mid-dose COG (120 mg/kg), and low-dose COG (60 mg/kg). Rat arthritis was induced by injection of Freund's complete adjuvant in the hind paws. All treatment started from the day the arthritis was induced. The edema degree of the adjuvant injection location was determined on days 1, 3, 5, 7, 9, 11, 13, 15, 17, 20, 23 and the opposite side was observed on days 11, 13, 15, 17, 20, 23 after the injection of adjuvant. All rats were sacrificed on day 24 after the injection of adjuvant for microscopic examination of the ankle, and for the study of the immunological molecular mechanism. The results showed that the COG significantly suppressed both the primary and secondary edema, improved pathological injuries of adjuvant arthritis (AA) rat ankles, significantly suppressed the proliferation of T lymphocytes and DTH reaction. It significantly suppressed IL-1, IL-6 and TNF-αproduction from peritoneal macrophages and PGE2 in plasma. In conclusion, the Cornus officinalis glucosides (COG) is able to prevent and cure the rat adjuvant-induced arthritis, and can suppress the production of pro-inflammatory cytokine IL-1, IL-6, TNF-αand PGE2.
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Effect of Cornus officinalis glycoside on adjuvant-induced arthritis in rats |
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| Shi Ping ZHAO,Jian Min LI,Gui Xiang FU and Yong ZHOU Institute of Clinical Medical Sciences,China-Japan Friendship Hospital,Beijing,P. R. China Beijing University of Traditional Chinese Medicine,Beijing,P. R. China. Effect of Cornus officinalis glycoside on adjuvant-induced arthritis in rats[J]. Chinese Journal of Microbiology and Immunology, 2006, 0(3) |
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| Authors: | Shi Ping ZHAO Jian Min LI Gui Xiang FU Yong ZHOU Institute of Clinical Medical Sciences China-Japan Friendship Hospital Beijing P. R. China Beijing University of Traditional Chinese Medicine Beijing P. R. China |
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| Abstract: | |
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| Keywords: | Cornus officinalis glucosides (COG) Adjuvant-induced arthritis |
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