皮肤及眼球外原发性恶性黑色素瘤临床病理分析

研究皮肤及眼球外原发性恶性黑色素瘤的临床与病理特征，以提高临床早期诊断率。方法对１８例皮肤及眼球外原发性恶性黑色素瘤进行临床资料分析，病理组织学、免疫组化及电镜研究。结果本组患者平均年龄５１．６岁，以女性为主。

Primary Malignant Extra-cutaneous and Extra-ocular Melanoma:Clinicopathological Analysis

Objective To investigate clinical manifestations and pathological features of primary malignant extra cutaneous and extra ocular melanoma.Methods Eighteen cases of primary malignant extra cutaneous and extra ocular melanoma were studied by pathohistology,electron microscope,and immunohistochemistry in which a panel of monoclonal antibodies against S 100 protein,HMB 45 and Vimentin were used and their clinical information was analyzed.Results The average age of patients was 51.6 years old and female was in the majority.Locally,5 cases were at rectum and canalis analis,4 cases at canitas nasi and antrum,2 cases at buccal mucous membrane,each one case at conjunctiva,urinary bladder,vagina,labium minus,cervix,bone and breast.Histologically,the shapes of tumor varied,it was like both carcinoma and sarcoma.Melanin granules appeared in 16 cases and non colored in 2 cases.Immunohistochemically,S -100 protein,HMB 45 and Vimentin antigen expressions were positive in tumor cells.Melanin bodies of different periods were shown in 6 cases by electron microscope.Conclusion Our study suggested that melanoma is derived not only from the cutaneous chromatophore,but also from the remaining neural crest cell of mucous membrane and mesenchymal tissue.