非小细胞肺癌中P—gp,p53,bcl—2蛋白表达及其相关性研究

目的 研究非小细胞肺癌（ＮＳＣＬＣ）中ｐ５３、ｂｃｌ－２蛋白以及耐多药基因ＭＤＲ１产物Ｐ－糖蛋白（Ｐ－ｇｐ）的表达及相互关系，探讨它们在ＮＳＣＬＣ发展、预后及耐药中的作用。方法 采用免疫组化Ｓ－Ｐ法，对６０例ＮＳＣＬＣ及其癌旁正常肺组织中ｐ５３、ｂｃｌ－２蛋白和Ｐ－ｇｐ进行检测。结果 ｐ５３、ｂｃｌ－２蛋白及Ｐｇｐ在ＮＳＣＬＣ中表达明显高于癌旁正常组织（Ｐ〈０．０１）。两者都与患者预后显著负相关（

Expression of MDR1 Gene Product P glycoprotein,p53 and bcl-2 Protein in Non small Cell Lung Cancer

Objective To observe the expression of p53,bcl 2 protein and MDR1 P gp in non small cell lung cancer(NSCLC) and study their effects in NSCLC.Methods Sixty cases of NSCLC and tumor surrounding normal lung tissues were examined with immunohistochemistry technique.Results The positive rates of p53,bcl 2 protein and MDR1 P gp in NSCLC were 51.7%,61.7% and 63.3% respectively,which were higher than that in normal controls( P <0.01).The three kinds of protein expression were related with prognosis,and not related with histological subtype( P >0.05).The expression of p53 protein was related with differential degree of NSCLC.The expression of p53 protein was not related with bcl 2 and P gp,but the expression of P gp was related with bcl 2 in NSCLC.Conclusion The expression of p53,bcl 2 protein and P gp are correlated with the development of NSCLC,and have important value on predicting the prognosis of NSCLC.There may be some relationship between MDR1 and bcl 2 during the development of NSCLC.