乳腺癌中PS2蛋白表达与ER,PR及预后的关系

探讨ＰＳ２蛋白在乳腺癌中的表达及其与ＥＲ、ＰＲ和患者预后的关系，方法应用ＬＳＡＢ免疫组织化学方法检测ＰＳ２蛋白在１０５例乳腺癌中的表达。结果ＰＳ２在乳腺癌中的表达率为５０．４８％（５３／１０５）。４３例ＥＲ和ＰＲ均为阳性者中，有３３例ＰＳ２表达阳性，阳性率为７６．７４％（３３／４３）；而４０例ＥＲ和ＰＲ均为阴性者中，仅有９例呈ＰＳ２表达阳性，阳性率为２２．５０％（９／４０，Ｐ〈０．０１。生存５年以

Relationship between PS_2 Protein Expression and ER,PR and Prognosis in Breast Cancer

Objective To study the relationship between the expression of PS 2 protein and estrogen receptor(ER) and progesterone receptor(PR) status and prognosis in breast cancer.Methods Using immunohistochemical method,PS 2 protein expressions in the 105 cases of breast cancer were detected.Results The positive rate of PS 2 protein was 50.48%(53/105) in the 105 patients.The positive rate of PS 2 in the patients who survived over five years or more was 56.96%(45/79),which was higher than that of those who lived less than five years(30.77%,8/26).In the patients with ER and PR( ),the positive rate of PS 2 was higher( 76.74 ,33/43),than that of those with ER and PR(-)(22.5%,9/40).Conclusion The expression of PS 2 protein was positively correlated with the 5 year Survival and ER and PR in breast cancer.It could be considered as a prognostic predictor,and detection of PS 2 protein expression was useful for treatment of breast cancer.