| 肺癌p53蛋白和增殖细胞核抗原的检测及其意义 |
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| 引用本文： | 吕福东 张海青. 肺癌p53蛋白和增殖细胞核抗原的检测及其意义[J]. 实用癌症杂志, 2000, 15(5): 485-486 |
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| 作者姓名： | 吕福东 张海青 |
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| 作者单位： | 北京市结核病胸部肿瘤研究所 |
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| 摘 要： | 目的：探讨ｐ５３蛋白、ＰＣＮＡ联合表达在临床中的意义。方法应用免疫组织化学Ｓ－Ｐ法检测１０１例肺癌中ｐ５３蛋白、ＰＣＮＡ的表达。结果ｐ５３蛋白在肺癌组织中有较高的表达。总阳性率为５９．４％（６０／１０１）。Ｐ５３蛋白表达与肿瘤分化程度呈正相关（Ｐ〈０．０５）。而与肺癌患者的生存期呈负相关（Ｐ〈０．０１）。Ｐ５３蛋白表达与ＰＣＮＡ染色密切相关（Ｐ〈０．０５）。结论Ｐ５３蛋白表达可作为判断肺癌患者预后
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| 关 键 词： | p53蛋白 增殖细胞核抗原 免疫组织化学 肺肿瘤 |
Expression and Significance of p53 Protein and PCNA in Primary Lung Cancer |
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| LU Fu-dong,ZHANG Hai-qing,HUANG Zhi-ying,et al.. Expression and Significance of p53 Protein and PCNA in Primary Lung Cancer[J]. The Practical Journal of Cancer, 2000, 15(5): 485-486 |
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| Authors: | LU Fu-dong ZHANG Hai-qing HUANG Zhi-ying et al. |
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| Affiliation: | LU Fu-dong,ZHANG Hai-qing,HUANG Zhi-ying,et al. Dept. of Pathology,Beijing Tuberculosis and Thorax Tumor Institute,Beijing,101149 |
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| Abstract: | Objective To investigate the relationship between p53 protein and proliferating cell nuclear antigen(PCNA) and the clinical significance in primary lung cancer.Methods S-P immunohistochemistry method was used in 101 cases of primary lung cancer tissue.Results Abnomalities in p53 expression were found,the positive ratios was 59.4%(60/101).p53 overexpression were associated with tumor grading and survival time( P <0.05).A significantly higher PCNA expression score was found in the p53-positive samples( P <0.05).Conclusion This finding suggests that overexpression of p53 could be used as an independent prognostic factor for the patients with lung cancer. |
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| Keywords: | p53 protein Proliferating cell nuclear antigen Immunohistochemistry Lung neoplasms |
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