| MTS1的基因产物和CD44V6在胃癌中表达的研究 |
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| 引用本文： | 范开席 陈黎. MTS1的基因产物和CD44V6在胃癌中表达的研究[J]. 实用癌症杂志, 2000, 15(6): 588-590 |
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| 作者姓名： | 范开席 陈黎 |
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| 作者单位： | 山东省肿瘤医院!250117 |
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| 基金项目： | 山东省医学科学院科研经费资助!(批准文编号 :980 2 0 4 0 2 3) |
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| 摘 要： | 目的：探讨ＭＴＳ１和ＣＤ４４Ｖ６在胃癌中的表达规律及其临床意义。方法：应用免疫组织化学ＬＳＡＢ方法，对６５例胃癌中ＭＴＳ１和ＣＤ４４Ｖ６基因产物的表达进行检测。结果：ＭＴＳ１基因产物的表达与胃癌的预后呈正相关，与浸润、淋巴结转移呈负机关。ＣＤ４４Ｖ６的表达与胃癌的浸润、淋巴结转移呈正相关，与预后呈负相关。结论：ＭＴＳ１和ＣＤ４４Ｖ６参与了胃癌的发展过程，并与胃癌的部分生物学行为有关，是胃癌诊断和预
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| 关 键 词： | 胃癌 MTS1基因 CD44V6基因 免疫组织化学 |
Expression of MTS1 Gene Products and CD44V6 in Gastric Cancer |
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| FAN Kai-xi,CHEN Li,ZHONG Wei-xia,et al.. Expression of MTS1 Gene Products and CD44V6 in Gastric Cancer[J]. The Practical Journal of Cancer, 2000, 15(6): 588-590 |
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| Authors: | FAN Kai-xi CHEN Li ZHONG Wei-xia et al. |
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| Affiliation: | FAN Kai-xi,CHEN Li,ZHONG Wei-xia,et al. Second Department of Internal Medicine,Shangdong Tumor Hospital,Jinan,250117 |
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| Abstract: | Objective To study the expression of MTS1 and CD44V6 in gastric cancer and its clincial significance.Methods MTS1 and CD44V6 gene products were observed in 65 cases of gastric cancer with LSAB immunohistochemical methods.Results Expression of MTS1 was positively related to the prognosis of patients,and negatively related to invasion depth and lymph node metastasis.Expression of CD44 was positively related to the invasion depth and lymph node metastasis,and negatively related to the prognosis of patients.Conclusion MTS1 and CD44V6 may play some roles in the development of gastric cancer,and were related with partial biological behavior.Expression of MTS1 and CD44V6 may serve as an important molecular-biological indicator of diagnosis and prognosis in gastric cancer. |
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| Keywords: | Gastric cancer MTS1 gene CD44V6 gene p16 protein Immunohistochemistry |
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