| 肺癌中粘附分子CD44和癌基因cyclinD1的表达 |
| |
| 引用本文： | 路名芝 刘勇. 肺癌中粘附分子CD44和癌基因cyclinD1的表达[J]. 实用癌症杂志, 2000, 15(5): 487-488 |
| |
| 作者姓名： | 路名芝 刘勇 |
| |
| 作者单位： | 江西省人民医院病理科 |
| |
| 基金项目： | 江西省卫生厅科研基金!资助 (编号 :980 0 2 1 ) |
| |
| 摘 要： | 目的探讨肺癌中粘附子分子ＣＤ４４和癌基因ｃｙｃｌｉｎＤ１的表达意义。方法应用Ｓ－Ｐ免疫组织化学方法研究６２例肺癌组织中ＣＤ４４和ｃｙｃｌｉｎＤ１的表达情况。结果６２例肺癌组织中ＣＤ４４和ｃｙｃｌｉｎＤ１的阳性率分别为７１．０％和５０．０％。腺癌和鳞癌的ＣＤ４４的阳性率明显高于小细胞癌（Ｐ〈０．０５）；淋巴结转移阳性组ＣＤ４４的表达显著高于阴性组（Ｐ〈０．０１，γ＝０．５４）。不同组织类型肺癌中ｃｙ
|
| 关 键 词： | 肺癌 粘附分子CD44 癌基因 cyclinD1 基因表达 |
Expression of CD44 and Cyclin D1 in Human Lung Carcinoma |
| |
| Abstract: | Objective To study the expressions of CD44 and cyclin D1 in human lung carcinoma.Methods By S-P immunohistochemical methods,the expressions of CD44 and cyclin D1 protein in 62 cases of human lung carcinoma was studied.Results The positive expressions of CD44 and cyclin D1 protein were 71.0% and 50.0% respectively.A significant correlation was found between CD44,cyclin D1 protein overexpression and lymph node metastasis( P <0.01).No significant correlation between the expressions of CD44 and cyclin D1 protein was found.Conclusion The overexpressions of CD44 and cyclin D1 protein play an important role in metastasis of lung carcinoma. |
| |
| Keywords: | Lung neoplasms Gene Metastasis Immunohistochemistry |
| 本文献已被 CNKI 维普 等数据库收录！ |
