肺癌中粘附分子CD44和癌基因cyclinD1的表达 |
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引用本文: | 路名芝 刘勇. 肺癌中粘附分子CD44和癌基因cyclinD1的表达[J]. 实用癌症杂志, 2000, 15(5): 487-488 |
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作者姓名: | 路名芝 刘勇 |
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作者单位: | 江西省人民医院病理科 |
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基金项目: | 江西省卫生厅科研基金!资助 (编号 :980 0 2 1 ) |
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摘 要: | 目的探讨肺癌中粘附子分子CD44和癌基因cyclinD1的表达意义。方法应用S-P免疫组织化学方法研究62例肺癌组织中CD44和cyclinD1的表达情况。结果62例肺癌组织中CD44和cyclinD1的阳性率分别为71.0%和50.0%。腺癌和鳞癌的CD44的阳性率明显高于小细胞癌(P〈0.05);淋巴结转移阳性组CD44的表达显著高于阴性组(P〈0.01,γ=0.54)。不同组织类型肺癌中cy
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关 键 词: | 肺癌 粘附分子CD44 癌基因 cyclinD1 基因表达 |
Expression of CD44 and Cyclin D1 in Human Lung Carcinoma |
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Abstract: | Objective To study the expressions of CD44 and cyclin D1 in human lung carcinoma.Methods By S-P immunohistochemical methods,the expressions of CD44 and cyclin D1 protein in 62 cases of human lung carcinoma was studied.Results The positive expressions of CD44 and cyclin D1 protein were 71.0% and 50.0% respectively.A significant correlation was found between CD44,cyclin D1 protein overexpression and lymph node metastasis( P <0.01).No significant correlation between the expressions of CD44 and cyclin D1 protein was found.Conclusion The overexpressions of CD44 and cyclin D1 protein play an important role in metastasis of lung carcinoma. |
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Keywords: | Lung neoplasms Gene Metastasis Immunohistochemistry |
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