大鼠神经端侧缝合的实验研究

目的：为进一步了解神经端侧缝合后再生的可能性。方法：用大鼠进行研究，实验分五组：Ａ组，将切断的腓神经远端与正常胫神经干行端侧缝合，保留缝合部胫神经外膜；Ｂ组，同Ａ组，缝合部胫神经外膜予以去除（“开窗”）；Ｃ组，将一神经移植段的两端分别与正常胫神经干和切断的腓神经远端神经干行“开窗”的端侧缝合；Ｄ组，将胫神经切断，近端与切断的腓神经远端神经干行“开窗”的端侧缝合。Ｅ组对照：仅切断腓神经。术后不同时期分别行电生理、组织学、神经纤维计数等检查。结果：鼠神经端侧缝合后腓神经远端有不同数量的有髓神经纤维再生。结论：动物鼠类神经端侧缝合能够再生

THE EXPERIMENTAL STUDY OF TERMINOLATERAL NEURORRHAPHY IN RATS

Objective:To know the possibility of nerve regeneration after terminolateral neurorrhaphy (TLN).Methods:Four experimental groups were made:Group A,the distal end of the severed peroneal nerve was sutured end to side with the normal tibial nerve trunk,the tibial epineurium at the suture site was not removed;Group B,nerve TLN was performed as in group A,except that the tibial epineurium at the suture site was removed(windowing);Group C,the two ends of a nerve graft were sutured end to side respectively with the windowed normal tibial nerve trunk and the windowed trunk of the distal part of the severed peroneal nerve;Group D,the tibial nerve was severed,the proximal end of it was sutured end to side with the windowed trunk of the distal part of the severed peroneal nerve.Results:One control group was made:the peroneal nerve was severed but not repaired.Electrophysiological examination three months later showed that the percent of rats of each group whose tibialis anterior muscle showed obvious M waves were:Group A,90%;Group B,100%;Group C,80%;Group D,100%;Group E,0%.Myelinated nerve fibers of various number ere found in the distal peroneal nerve of every experimental group.Conclusion:Experimental study in rats showed that nerve can be regenerated after terminolateral neurorrhaphy