Temperature Measurement During Polymerization of Bone Cement in Percutaneous Vertebroplasty: An In Vivo Study in Humans |
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Authors: | Giovanni Carlo Anselmetti Antonio Manca Khanna Kanika Kieran Murphy Haris Eminefendic Salvatore Masala Daniele Regge |
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Institution: | (1) Interventional Radiology Unit, Institute for Cancer Research and Treatment (IRCC), Strada Provinciale 142, Km. 3,95, 10060 Candiolo, Turin, Italy;(2) Ph.D. Scholarship in Biomedical Sciences, University of Sassari, Sassari, Italy;(3) Johns Hopkins Hospital, Radiology and Radiological Science, 600 North Wolfe Street, Baltimore, MD 21287, USA;(4) Radiology Unit, Institute for Cancer Research and Treatment (IRCC), Strada Provinciale 142, Km. 3,95, 10060 Candiolo, Turin, Italy;(5) Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, “Tor Vergata” University General Hospital, V. le Oxford 81, 00133 Rome, Italy |
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Abstract: | Aim of the study was to “in vivo” measure temperature, during percutaneous vertebroplasty (PV), within a vertebral body injected
with different bone cements. According to the declaration of Helsinki, 22 women (60–80 years; mean, 75 years) with painful
osteoporotic vertebral collapse underwent bilateral transpedicular PV on 22 lumbar vertebrae. Two 10-G vertebroplasty needles
were introduced into the vertebra under digital fluoroscopy; a 16-G radiofrequency thermoablation needle (Starburst XL; RITA
Medical System Inc., USA), carrying five thermocouples, was than coaxially inserted. Eleven different bone cements were injected
and temperatures were measured every 30 s until temperatures dropped under 45°C. After the thermocouple needle was withdrawn,
bilateral PV was completed with cement injection through the vertebroplasty needle. Unpaired Student’s t-tests, Kruskal–Wallis test, and Wilcoxon signed rank test were used to evaluate significant differences (p < 0.05) in peak temperatures, variations between cements, and clinical outcome. All procedures were completed without complications,
achieving good clinical outcomes (p < 0.0001). Regarding average peak temperature, cements were divided into three groups: A (over 60°C), B (from 50° to 60°C),
and C (below 50°C). Peak temperature in Group A (86.7 ± 10.7°C) was significantly higher (p = 0.0172) than that in Groups B (60.5 ± 3.7°C) and C (44.8 ± 2.6°C). The average of all thermocouples showed an extremely
significant difference (p = 0.0002) between groups. None of the tested cements maintained a temperature ≥45°C for more than 30 min. These data suggest
that back-pain improvement is obtained not by thermal necrosis but by mechanical consolidation only. The relative necrotic
thermal effect in vertebral metastases seems to confirm that analgesia must be considered the main intent of PV. |
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Keywords: | Vertebroplasty Bone cement Temperature Polymethylmethacrylate Radiofrequency ablation |
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