聚六亚甲基碳酸酯聚氨酯脲的抗凝血性

[目的]评价自合成的聚六亚甲基碳酸酯聚氨酯脲(polyhexymethylene carbonate polyurethane urea PCU)的抗凝血性.[方法]使用动态凝血时间、血小板黏附、微球柱、抗凝血酶活性等试验,将PCU的实验结果与Chronoflex(美国聚氨酯牌号)和玻璃相比较.[结果]动态凝血时间的试验PCU与Chronoflex的凝血速度比玻璃慢,凝血程度比玻璃小.血小板黏附试验和微球柱试验的试验PCU和Chronoflex样品表面黏附的血小板数目比玻璃少,变形程度比玻璃轻.抗凝血酶活性的试验PCU和Chronoflex样品的白陶土部分凝血酶时间、凝血酶原时间、凝血酶时间的测定值均大于玻璃.[结论]PCU具有良好的抗凝血性能,并且抗凝血性能与美国产品Chronoflex很相近.

Antithrombogenicity of Polyhexymethylene Carbonate Polyurthane Urea

To evaluate antithrombogenicity of polyhexymethylene carbonate polyurethane urea (PCU) synthesized. Dynamic clotting time test, platelet adhesion test, microsphere column test, and antithrombin activity test were used and Chronoflex and glass specimens were used as control. The results of PCU specimens were compared with those of Chronoflex (American product) and glass specimens. The dynamic clotting time test showed that blood clotting rates of PCU and Chronoflex was lower than that of glass. Blood clotting extent of PCU and Chronoflex was less than that glass. The platelet adhesion test and microsphere column test indicated that the number of platelets adhered on surface of PCU and Chronoflex specimens was less than that glass. The deformation was lighter than the glass. The antithrombin activity test demonstrated that the KPTT, PT,TT values of PCU and Chronoflex were longer than those of glass.[Conclusion] PCU displays as good for antithrombogenicity as that of American product Chronoflex.