Interaction of HPV-18 and nitrosomethylurea in the induction of squamous cell carcinoma |
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Authors: | Garrett Lenora R; Perez-Reyes Nuria; Smith Patricia P; McDougall James K |
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Institution: | 1Division of Cancer Biology, Fred Hutchinson Cancer Research Center 1124 Columbia St, Seattle, WA 98104
2Department of Pathology, University of Washington Seattle WA 98195, USA |
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Abstract: | A strong correlation exists between the presence of specifictypes of human papillomavirus (HPV) and the development of anogenitalcancer, as well as significant epidemiologic evidence suggestingsmokers are at increased risk of developing cervical, vulvarand/or anal carcinomas. Primary and human papillomavirus type18 (HPV-8)-immortalized human keratinocytes were used to addressthe co-carcinogenic potential of HPV and nitrosomethylurea (NMU)in tumorigenesis. Only cells containing HPV-18 and treated withNMU and the tumor-promoting phorbol ester, TPA, were transformedto a malignant phenotype. An in vitro system is described whichinitiates studies involving the mechanisms of HPV and chemicalcarcinogen co-operation in the etiology of squamous cell carcinomas. |
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