| 乌苏烷型降三萜类化合物研究进展 |
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| 引用本文： | 宋乐苓,王风玲,王燕,张浩超,孙敬勇.乌苏烷型降三萜类化合物研究进展[J].中草药,2017,48(22):4826-4830. |
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| 作者姓名： | 宋乐苓 王风玲 王燕 张浩超 孙敬勇 |
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| 作者单位： | 济南大学 山东省医学科学院 医学与生命科学学院, 山东 济南 250200;山东省医学科学院药物研究所, 山东 济南 250062,山东省医学科学院药物研究所, 山东 济南 250062;国家卫生部生物技术药物重点实验室, 山东 济南 250062;山东省罕少见病重点实验室, 山东 济南 250062,山东省医学科学院药物研究所, 山东 济南 250062;国家卫生部生物技术药物重点实验室, 山东 济南 250062;山东省罕少见病重点实验室, 山东 济南 250062,济南大学 山东省医学科学院 医学与生命科学学院, 山东 济南 250200;山东省医学科学院药物研究所, 山东 济南 250062,山东省医学科学院药物研究所, 山东 济南 250062;国家卫生部生物技术药物重点实验室, 山东 济南 250062;山东省罕少见病重点实验室, 山东 济南 250062 |
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| 基金项目： | 山东省高等学校科技计划项目（J15LM07）；山东省医学科学院医药卫生科技创新工程 |
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| 摘 要： | 乌苏烷型降三萜是在乌苏烷三萜碳骨架上减少1个或几个甲基,按其缺少甲基的位置可分为23-降、24-降、28-降、29-降、30-降、2-降、3-降和3,24-降8种类型。其药理活性包括抗癌、抗炎、抗菌和抑制酰基辅酶A-胆固醇酰基转移酶(ACAT)等。结合国内外有关乌苏烷型降三萜类化合物的文献,对乌苏烷型降三萜类化合物的植物分布、化学结构特征及药理活性3方面进行综述,为此类化合物的进一步研究提供参考依据。
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| 关 键 词： | 乌苏烷型降三萜 抗癌 抗炎 抗菌 酰基辅酶A-胆固醇酰基转移酶 |
| 收稿时间： | 2017/7/7 0:00:00 |
Research progress on nor-ursane triterpenes |
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| SONG Le-ling,WANG Feng-ling,WANG Yan,ZHANG Hao-chao and SUN Jing-yong.Research progress on nor-ursane triterpenes[J].Chinese Traditional and Herbal Drugs,2017,48(22):4826-4830. |
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| Authors: | SONG Le-ling WANG Feng-ling WANG Yan ZHANG Hao-chao and SUN Jing-yong |
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| Institution: | School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, China;Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China,Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China;Key Laboratory for Biotech-Drugs Ministry of Health, Jinan 250062, China;Key Laboratory for Rare & amp;Uncommon Diseases of Shandong Province, Jinan 250062, China,Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China;Key Laboratory for Biotech-Drugs Ministry of Health, Jinan 250062, China;Key Laboratory for Rare & amp;Uncommon Diseases of Shandong Province, Jinan 250062, China,School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, China;Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China and Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China;Key Laboratory for Biotech-Drugs Ministry of Health, Jinan 250062, China;Key Laboratory for Rare & amp;Uncommon Diseases of Shandong Province, Jinan 250062, China |
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| Abstract: | Nor-ursane triterpenes are formed by the reduction of one or several methyl groups on the ursane triterpene carbon skeleton. According to the position of vacant methyl, they can be divided into eight types, including 23-nor, 24-nor, 28-nor, 29-nor, 30-nor, 2-nor, 3-nor, and 3,24-nor. Moreover, nor-ursane triterpenes have several pharmacological effects such as anti-cancer, anti-inflammatory, anti-bacterial, inhibition of acyl cholesterol acyl transferase (ACAT) and so on. In this study, more than 30 relevant literatures of nor-ursane triterpenoid compounds at home and abroad were reviewed. The plant distribution, pharmacological activity and structural characteristics of nor-ursane triterpenes were studied. Therefore, this review may provide the basis for further study of this type of compound. |
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| Keywords: | nor-ursane triterpenes anti-cancer anti-inflammatory anti-bacterial acyl cholesterol acyl transferase |
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