| 茜草地上部分木脂素类成分研究 |
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| 引用本文： | 张茂婷,杨柳,胡江苗,张虹,施香琴,刘守金.茜草地上部分木脂素类成分研究[J].中草药,2017,48(23):4856-4859. |
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| 作者姓名： | 张茂婷 杨柳 胡江苗 张虹 施香琴 刘守金 |
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| 作者单位： | 安徽中医药大学药学院, 安徽 合肥 230012,中国科学院昆明植物研究所, 植物化学与西部植物资源持续利用国家重点实验室, 云南 昆明 650201,中国科学院昆明植物研究所, 植物化学与西部植物资源持续利用国家重点实验室, 云南 昆明 650201,安徽中医药大学药学院, 安徽 合肥 230012;安徽道地药材品质提升协同创新中心, 安徽 合肥 230012,安徽中医药大学药学院, 安徽 合肥 230012,安徽中医药大学药学院, 安徽 合肥 230012;安徽道地药材品质提升协同创新中心, 安徽 合肥 230012 |
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| 摘 要： | 目的对茜草Rubia cordifolia地上部分化学成分进行研究。方法利用硅胶、Sephadex LH-20、MCI等多种色谱材料进行分离纯化,根据波谱数据和理化性质鉴定化合物的结构。结果共分离得到11个木脂素类成分,分别鉴定为(-)-表丁香脂素(1)、开环异落叶松脂素(2)、(-)-3,4-二香草基四氢呋喃(3)、lignans(+)-demethoxypinoresinol(4)、(+)-丁香脂素(5)、异落叶松脂素(6)、橄榄树脂素(7)、(7S,8R)-二氢脱氢双松柏醇(8)、4,5′-二甲基落叶松脂醇(9)、(+)-7R,8S-5-methoxydihydrodehydroconifery alcohol(10)、5,5′-二甲氧基-7-氧代落叶松脂醇(11)。结论以上化合物均为首次从该植物中分离得到。
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| 关 键 词： | 茜草 木脂素 (−)-表丁香脂素 开环异落叶松脂素 橄榄树脂素 (7S, 8R)-二氢脱氢双松柏醇 |
| 收稿时间： | 2017/5/21 0:00:00 |
Study on lignan constituents from aerial part of Rubia cordifolia |
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| ZHANG Mao-ting,YANG Liu,HU Jiang-miao,ZHANG Hong,SHI Xiang-qin and LIU Shou-jin.Study on lignan constituents from aerial part of Rubia cordifolia[J].Chinese Traditional and Herbal Drugs,2017,48(23):4856-4859. |
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| Authors: | ZHANG Mao-ting YANG Liu HU Jiang-miao ZHANG Hong SHI Xiang-qin and LIU Shou-jin |
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| Institution: | College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China,State key Laboratory of Plant Chemistry and Sustainable Utilization of Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China,State key Laboratory of Plant Chemistry and Sustainable Utilization of Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China,College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China;Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, China,College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China and College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China;Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, China |
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| Abstract: | Objective To investigate the chemical constituents of the aerial part of Rubia cordifolia. Methods All compounds were isolated and purified by silica gel, Sephadex LH-20, and MCI column chromatography. Their structures were determined by physicochemical properties and spectral data. Results Eleven compounds were isolated and identified as:(−)-episyringaresinol (1), (−)-secoisolariciresinol (2), (−)-3,4-divanillyl tetrahydrofuran (3), lignans (+)-demethoxypinoresinol (4), (+)-syringaresinol (5), (+)-isolariciresinol (6), burselignan (7), (7S,8R)-dihydrodehydroconiferyl alcohol (8), 4,5''-dimethoxy-lariciresinol (9), (+)-7R,8S-5-methoxydihydrodehydroconifery alcohol (10), and 5,5''-dimethoxy-7-oxolariciresinol (11). Conclusion All compounds are isolated from this plant for the first time. |
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| Keywords: | Rubia cordifolia L lignans (−)-episyringaresinol (−)-secoisolariciresinol burselignan (7S, 8R)-dihydrodehydroconiferyl alcohol |
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