舒血宁注射液联合胞磷胆碱钠治疗突发性耳聋的疗效观察

目的探究舒血宁注射液联合胞磷胆碱钠注射液治疗突发性耳聋的有效性和安全性。方法选取陕西中医药大学附属医院2015年2月—2017年2月收治突发性耳聋患者97例,随机分成对照组(48例)和治疗组(49例)。对照组患者静脉滴注胞磷胆碱钠注射液,0.25 g加入5%葡萄糖注射液250 m L,1次/d;治疗组在对照组的基础上静脉滴注舒血宁注射液,10 m L加入5%葡萄糖注射液250 m L,1次/d。所有患者均规律治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者平均听阈和听力改善情况以及纯音电测听力图分型的分布、治疗后有效耳数和不良反应情况。结果治疗后,对照组和治疗组的临床总有效率分别为73.58%、94.44%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者平均听阈值明显降低(P0.05);且治疗组平均听阈值比对照组更低(P0.05)。治疗后,治疗组听力改善情况明显优于对照组(P0.05)。治疗后,两组患者上升型、平坦型、盆型患耳显著少于治疗前,同组治疗前后比较差异具有统计学意义(P0.05);且治疗后治疗组上升型、下降型、平坦型、盆型以及总耳的有效率显著高于对照组,两组比较差异具有统计学意义(P0.05)。治疗组患者不良反应发生率为8.16%,明显低于对照组的25.00%,两组比较差异具有统计学意义(P0.05)。结论舒血宁注射液联合胞磷胆碱钠注射液治疗突发性耳聋具有明显疗效,安全性较高,具有一定的临床推广应用价值。

Clinical observation of Shuxuening Injection combined with citicoline sodium in treatment of sudden deafness

Objective To explore the clinical efficacy and safety of Shuxuening Injection combined with citicoline sodium in treatment of sudden deafness. Methods Patients (97 cases) with sudden deafness in the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from February 2015 to February 2017 were randomly divided into control (48 cases) and treatment (49 cases) groups. Patients in the control group were iv administered with Citicoline Sodium Injection, 0.25 g added into 5% glucose injection 250 mL, once daily. Patients in the treatment group were iv administered with Shuxuening Injection on the basis of the control group, 10 mL added into 5% glucose injection 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, the average hearing threshold and the improvement of hearing, the distribution of pure tone audiometry and effective ears, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 73.58% and 94.44%, respectively, and there were differences between two groups (P<0.05). After treatment, the average hearing threshold in two groups was significantly decreased (P<0.05). And the average hearing threshold in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the improvement of hearing in the treatment group was significantly better than that in the control group (P<0.05). After treatment, the ascending ears, flat ears, and pot ears in two groups were less than those before treatment, and there was difference between two groups (P<0.05). And the effective rate of the ascending ears, declining ears, flat ears, pot ears, and all effective ears in the treatment group were significantly higher than that in the control group, with significant difference between two groups (P<0.05). During the treatment, the incidence of adverse reactions in the treatment was 8.16%, which was significantly lower than 25.00% in the control group, with significant difference between two groups (P<0.05). Conclusion Shuxuening Injection combined with citicoline sodium have obviously curative effect in treatment of sudden deafness with high safety, which has a certain clinical application value.