| 拳距瓜叶乌头二萜生物碱成分研究 |
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| 引用本文： | 何丹,刘王艳,郭成鑫,李贵琼,段晓燕,熊娇,沈勇.拳距瓜叶乌头二萜生物碱成分研究[J].中草药,2017,48(19):3915-3920. |
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| 作者姓名： | 何丹 刘王艳 郭成鑫 李贵琼 段晓燕 熊娇 沈勇 |
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| 作者单位： | 云南农业大学农学与生物技术学院, 云南 昆明 650201,云南农业大学农学与生物技术学院, 云南 昆明 650201,云南农业大学农学与生物技术学院, 云南 昆明 650201,云南农业大学农学与生物技术学院, 云南 昆明 650201,云南农业大学农学与生物技术学院, 云南 昆明 650201,云南农业大学农学与生物技术学院, 云南 昆明 650201,云南农业大学农学与生物技术学院, 云南 昆明 650201 |
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| 基金项目： | 国家自然科学基金资助项目（21362045）；云南省科技惠民专项（2016RA046） |
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| 摘 要： | 目的对拳距瓜叶乌头Aconitum hemsleyanum var.circinatum的块根进行化学成分研究。方法采用柱色谱方法进行分离纯化,结合波谱数据(~1H-NMR、~(13)C-NMR、MS)进行结构鉴定。结果从拳距瓜叶乌头块根总生物碱中共分离得到17个二萜生物碱,分别鉴定为黄草乌碱丁(1)、8-甲氧基黄草乌碱丁(2)、贡乌生(3)、塔拉地萨敏(4)、查斯曼宁(5)、8-甲氧基塔拉胺(6)、14-乙酰塔拉胺(7)、8-去乙酰滇乌碱(8)、crassicautine(9),crassicaudine(10)、粗茎乌头碱甲(11)、黄草乌碱丙(12)、黄草乌碱甲(13)、滇乌碱(14)、transconitine B(15)、工布乌碱(16)、大渡乌碱(17)。结论化合物2、3、6、7、9、12~16为首次从该植物中分离得到。
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| 关 键 词： | 毛茛科 拳距瓜叶乌头 二萜生物碱 8-甲氧基黄草乌碱丁 贡乌生 黄草乌碱丙 滇乌碱 |
| 收稿时间： | 2017/3/28 0:00:00 |
Diterpenoid alkaloids in roots of Aconitum hemsleyanum var. circinatum |
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| HE Dan,LIU Wang-yan,GUO Cheng-xin,LI Gui-qiong,DUAN Xiao-yan,XIONG Jiao and SHEN Yong.Diterpenoid alkaloids in roots of Aconitum hemsleyanum var. circinatum[J].Chinese Traditional and Herbal Drugs,2017,48(19):3915-3920. |
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| Authors: | HE Dan LIU Wang-yan GUO Cheng-xin LI Gui-qiong DUAN Xiao-yan XIONG Jiao and SHEN Yong |
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| Institution: | College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, China,College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, China,College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, China,College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, China,College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, China,College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, China and College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, China |
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| Abstract: | Objective To study the chemical constituents in the roots of Aconitum hemsleyanum var. circinatum. Methods The constituents were isolated and purified by silica gel chromatography from the roots of Aconitum hemsleyanum var. circinatum, and the structures were identified by spectral analysis (1H-NMR, 13C-NMR, and MS). Results Seventeen compounds were isolated from Aconitum hemsleyanum var. circinatum and characterized as sachaconitine (1), 8-O-methylsachaconitine (2), liljestrandisine (3), talatisamine (4), chasmannine (5), 8-O-methyltalatisamine (6), 14-O-acetyltalatisamine (7), 8-deacetyl-yunaconitine (8), crassicautine (9), crassicaudine (10), crassicauline A (11), vilmorianine C (12), vilmorianine A (13), yunaconitine (14), transconitine B (15), kongboendine (16), and franchetine (17). Conclusion Seventeen compounds are isolated from Aconitum hemsleyanum var. circinatu. Compounds 2-3, 6-7, 9, and 12-16 are isolated from Aconitum hemsleyanum var. circinatum for the first time. |
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| Keywords: | Ranunculaceae Aconitum hemsleyanum Pritz var circinatum W T Wang diterpenoid alkaloids 8-O-methylsachaconitine liljestrandisine vilmorianine C yunaconitine |
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