稀有原人参三醇型皂苷的生物转化研究进展

人参是传统的名贵中药,其主要活性成分为人参皂苷,对心血管、肿瘤、中枢神经系统等疾病有显著的疗效。特别是原人参三醇(PPT)型皂苷Rh_1具有良好的抗炎、抗过敏、提高记忆力等活性。人参皂苷Rh_1仅微量地存在于人参、三七、西洋参中。生物转化方法制备稀有人参皂苷已成为一种有效的途径。综述利用生物转化方法对PPT型人参皂苷进行转化,生成稀有人参皂苷的研究进展,以期为稀有人参皂苷的进一步开发利用提供参考。

Advances in biotransformation of protopanaxatriol rare ginsenoside

Ginseng is a traditional medicine in Asian countries. Ginsenoside has the main active ingredient, exhibit cardiovascular, tumor, and central nervous system activities. In particular, protopanaxatriol-type ginsenosides Rh₁, exhibits anti-inflammatory, anti-allergic, and memory improvement activities. Ginsenoside Rh₁ is only found in trace amounts in Panax ginseng, Panax pseudoginseng var. notoginseng, and Panax quinquefolius. Biotransformation of rare ginsenosides has become an effective way. In this paper, the research progress of transformation of ginsenoside saponins by biotransformation to produce rare ginsenoside Rh₁ is reviewed, which provides a useful reference for the further development and preparation of ginsenoside Rh₁.