Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats |
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| Authors: | Shimizu Takahiro Okada Shoshiro Yamaguchi Naoko Sasaki Tsuyoshi Lu Lianyi Yokotani Kunihiko |
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| Affiliation: | Department of Pharmacology, Graduate School of Medicine, Kochi University, Nankoku, Japan. shimizu@med.kochi-u.ac.jp |
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| Abstract: | Plasma adrenaline is originated from adrenal medulla, while plasma noradrenaline reflects the release from sympathetic nerves in addition to the secretion from adrenal medulla. The present study was designed to characterize the source of plasma catecholamines induced by centrally administered histamine, with regard to the brain prostanoids. Intracerebroventricularly (i.c.v.) administered histamine (1, 5 and 10 microg/animal) elevated plasma noradrenaline and adrenaline (noradrenaline
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| Keywords: | Histamine Cyclooxygenase-1 Thromboxane A2 Catecholamines Adrenal medulla |
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