中心静脉导管引流并心包内化疗治疗肺癌致心包积液

目的：探讨控制肺癌所致恶性心包积液的有效治疗方式。方法：16例肺癌致恶性心积液患者，经中心静脉导管引净积液后心包内注入顺铂、足叶乙甙，再持续引流积液至每日引流量少于50ml后撤管。结果：完全缓解13例、部分缓解2例，有效率93．8％；全组中位生存6．5个月，全组 死于心包积液未控或复发2例，全组出现胃肠道反应11例，胃髓抑制3例，经对症处理均缓解。结论：中心静脉导管引流心包积液并心包腔内注入顺铂、足叶乙甙是治疗肺癌致恶性心包积液较理想的治疗方法。

Pericardial Effusion in Patients with Lung Cancer Treated with Safe-Dwel Plus Drain and Intrapericardial Chemotherapy

Objective： The aim of this study was to approach an efficient way in the treatment of pericardial effusion of lung cancer. Methods： Sixteen patients with pericardial effusion of lung cancer are drained with Safe-Dwel Tlus, then cisplatin and etoposide were injected into the pericardial cavity, and the draining continually effusion to less 50 ml per day. Results： The total effective rate was 93.8％ with 13 cases of complete response rate and 2 cases of partial response rate. The median survival time was 6.5 months. 2 cases died from the relapse of pericardial effusion or no effect. Eleven cases had gastrointestinal tract reaction, and 3 cases with repression of bone marrow. However all side effects were controlled by treatment. Conclusion： Safe-Dwel Tlus drain with injecting cisplatin and etoposide into pericardial cavity may be a better way to control malignant pericardial effusion of lung cancer.