| 肝细胞糖原拮抗肝脏缺血再灌注损伤及其相关机理的研究 |
| |
| 引用本文： | 汤礼军,田伏洲,王雨,李晓军,尹致良. 肝细胞糖原拮抗肝脏缺血再灌注损伤及其相关机理的研究[J]. 中国普外基础与临床杂志, 1999, 6(4): 196-198 |
| |
| 作者姓名： | 汤礼军 田伏洲 王雨 李晓军 尹致良 |
| |
| 作者单位： | 成都军区总医院全军普外中心实验室,成都,610083 |
| |
| 摘 要： | 为了探讨增加细胞内糖原含量能否改善肝脏缺血再灌注损伤程度，本实验对３组糖原含量显著不同的兔肝脏缺血再灌注过程中的组织形态学，肝脏酶学，组织ＡＴＰ含量，细胞膜Ｃａ＾２＋－ＡＴＰ酶活性及胞浆内游离Ｃａ＾２＋浓度进行了观察。结果：糖原含量高的肝脏，其细胞能量代谢旺盛，细胞膜Ｃａ＾２＋－ＡＴＰ酶活性强，胞浆内游离Ｃａ＾２＋浓度相对稳定，组织结构及功能损作轻，本实验结果提示：缺血前增加肝脏糖含量可显著了拮抗
|
| 关 键 词： | 肝脏 糖原 肝缺血 再灌注损伤 |
EFFECT OF INTRACELLULAR GLYCOGEN ON LIVER ISCHEMIA-REPERFUSION AND ITS MECHANISM |
| |
| Tang Lijun,Tian Fuzhou,Wang Yu,et al.. EFFECT OF INTRACELLULAR GLYCOGEN ON LIVER ISCHEMIA-REPERFUSION AND ITS MECHANISM[J]. Chinese Journal of Bases and Clinics In General Surgery, 1999, 6(4): 196-198 |
| |
| Authors: | Tang Lijun Tian Fuzhou Wang Yu et al. |
| |
| Affiliation: | Tang Lijun,Tian Fuzhou,Wang Yu,et al. The PLA Centre of General Surgery,Chengdu General Hospital,Chengdu 610083 |
| |
| Abstract: | To investigate the effect of intracellular glycogen on liver ischemiareperfusion and its mechanism, histomorphological and enzymological changes, histic ATP contents, the activity of Ca2 ATPase on cytoplasmic membrane and intracellular free Ca2 concentration were observed during the ischemiareperfusion of three groups of rabbit livers with different glycogen content. We found that the more vigorous energy metabolism, the higher activity of Ca2 ATPase, the lower concentration of intracellular free Ca2 and the slighter injury of histic structure and function appeared in the liver with the more abundant glycogen. The results suggest that intracellular abundant glycogen may reduce liver ischemiareperfusion injury. |
| |
| Keywords: | LiverGlycogenIschemiareperfusion injuryAnimal experiment |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
