| CYP2J2的生理功能及其在心血管疾病中的作用 |
| |
| 引用本文： | 李钟玉,周宏灏. CYP2J2的生理功能及其在心血管疾病中的作用[J]. 医学综述, 2008, 14(11): 1619-1622 |
| |
| 作者姓名： | 李钟玉 周宏灏 |
| |
| 作者单位： | 中南大学临床药理研究所,长沙,410078 |
| |
| 摘 要： | CYP2J2是一种广泛存在于人体心血管系统、肾脏及肝脏的P450酶。在人体不仅参与外源性物质的代谢,同时还参与花生四烯酸的代谢。由于其分布与功能的特点,在人体心血管系统具有重要调控作用。现就CYP2J2的基因及相应突变,分布以及其生理功能进行简单综述。
|
| 关 键 词： | CYP2J2 环氧-二十碳三烯酸 基因多态性 心血管疾病 |
Physiological Functions of CYP2J2 and its Influence on Cardiovascular Diseases |
| |
| LI Zhong-yu,ZHOU Hong-hao. Physiological Functions of CYP2J2 and its Influence on Cardiovascular Diseases[J]. Medical Recapitulate, 2008, 14(11): 1619-1622 |
| |
| Authors: | LI Zhong-yu ZHOU Hong-hao |
| |
| Affiliation: | LI Zhong-yu,ZHOU Hong-hao.(Institute of Clinical Pharmacology,Xiangya School of Medicine,Central south University,Changsha 410078,China) |
| |
| Abstract: | As one of Human cytochromes P450,CYP2J2 is abundant in cardiovascular tissue and active in the metabolism of a variety of xenobiotics and arachidonic acid that make it to be one of the most important factor in cardiovascular system.This minireview will provide a general overview of CYP2J2 gene and its polymorphisms,distribution and physiological functions. |
| |
| Keywords: | CYP2J2 Expoxyeicosatrienoic acid Gene polymorphism Cardiovascular diseases |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
