补钙对废用性骨质疏松大鼠子代骨密度、超氧化物歧化酶和丙二醛的影响

为研究补钙对废用性骨质疏松仔鼠骨密度、血清超氧化物歧化酶 (SOD)和丙二醛 (MDA)的影响 ,选取 2 5只孕雌性SD大鼠分为 5组 ,单笼喂养 ,2～ 5组复制骨质疏松动物模型 ,1、2组喂普通饲料 ,作为对照 ,3～ 5组喂补钙实验饲料 ,每窝子鼠随机选取 3只与母鼠同笼喂养 ,观察仔鼠出生 37d后的各项指标 ,包括骨密度、SOD和MDA。结果表明各补钙组子鼠骨密度明显比阳性对照组增高 (P <0 0 5)。与阳性对照组相比 ,各补钙组的血清MDA明显降低 (P <0 0 1 ) ,而高生物钙组SOD明显升高 (P <0 0 5)。补钙对废用性骨质疏松仔鼠血清SOD和MDA有显著影响

Effect of calcium supplement on superoxide dismutase and malonaldehyde of disuse osteoporosis in young rats

Effects of Ca supplement on the bone mineral density(BMD), red blood cell superoxide dismutase(SOD), plasma malonaldehyde(MDA) of disused osteoporosis were studied in this paper. Twenty five healthy prcgnant SD rats were randemly divided into 5 groups, groups 2-5 were reproduced with patterns of animal osteoporosis. The diet in groups 1-2 was the basic diet, while the groups 3-5 experiment diets were supplemented with Ca. Selected 3 young rats, live with the mother rate each brood. The BMD, red blood cell SOD, plasma MDA were measured 37d later. The results showed that BMD level of young rats in Ca supplement groups is higher than vigorous groups ( P <0 05). The MDA in vigorous group was higher than Ca supplement, groups( P <0 01) and SOD was lower than high biologic calcium group( P <0 05). It was suggested that Ca supplementd certain effect on red blood cell SOD, plasma MDA of disused osteoporosis.