Cytotoxic withanolide constituents of Physalis longifolia |
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Authors: | Zhang Huaping Samadi Abbas K Gallagher Robert J Araya Juan J Tong Xiaoqin Day Victor W Cohen Mark S Kindscher Kelly Gollapudi Rao Timmermann Barbara N |
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Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, Kansas 66045, USA. |
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Abstract: | Fourteen new withanolides, 1-14, named withalongolides A-N, respectively, were isolated from the aerial parts of Physalis longifolia together with eight known compounds (15-22). The structures of compounds 1-14 were elucidated through spectroscopic techniques and chemical methods. In addition, the structures of withanolides 1, 2, 3, and 6 were confirmed by X-ray crystallographic analysis. Using a MTS viability assay, eight withanolides (1, 2, 3, 7, 8, 15, 16, and 19) and four acetylated derivatives (1a, 1b, 2a, and 2b) showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986), melanoma (B16F10 and SKMEL-28), and normal fetal fibroblast (MRC-5) cells with IC?? values in the range between 0.067 and 9.3 μM. |
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