Drug release behaviors of a pH sensitive semi-interpenetrating polymer network hydrogel composed of poly(vinyl alcohol) and star poly[2-(dimethylamino)ethyl methacrylate |
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| Authors: | Wu Wei Liu Jing Cao Shuqin Tan Hong Li Jianshu Xu Fujian Zhang Xiao |
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| Affiliation: | a College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China
b College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China |
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| Abstract: | A series of pH sensitive semi-interpenetrating polymer network (semi-IPN) structural hydrogels composed of poly(vinyl alcohol) (PVA) and 21-arm star poly[2-(dimethylamino)ethyl methacrylate] (star PDMAEMA) with different molecular weight were prepared. Riboflavin was used as a model drug to evaluate the drug loading capacities and drug release behaviors of the semi-IPN structural hydrogels. The molecular weight of the star PDMAEMA polymers was calculated by GPC, and the formation of semi-IPN structure was confirmed by FTIR and SEM. It was found that the molecular weight of star PDMAEMA has significant effect on the structure, swelling ratio and drug release behaviors of the semi-IPN hydrogel at different pH conditions. The results suggested that the PVA/star PDMAEMA-50,000 hydrogel exhibited highest swelling ratio and drug loading capacity. The pH-sensitive semi-IPN hydrogel based on star PDMAEMA could be a promising drug delivery system due to the controllable porous structure. |
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| Keywords: | Semi-interpenetrating polymer network hydrogel Star polymer pH-sensitive Swelling behaviors Drug release |
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