| 食管癌组织p53基因杂合性缺失的检测 |
| |
| 引用本文： | 李卫江,段金霞.食管癌组织p53基因杂合性缺失的检测[J].郑州大学学报(医学版),2004,39(3):499-501. |
| |
| 作者姓名： | 李卫江 段金霞 |
| |
| 作者单位： | 中原油田第二医院内科,范县,457532;南阳市中心医院检验科,南阳,473000 |
| |
| 摘 要： | 目的探讨食管癌p53基因杂合性缺失(LOH)与食管癌发生和发展的关系.方法应用荧光原位杂交技术对食管鳞状细胞癌、癌旁不典型增生组织及正常食管上皮各30例进行p53基因LOH检测.结果p53基因LOH检出率在正常食管上皮、不典型增生组织及鳞癌组织中分别为0,16.7%(5/30)和63.3%(19/30),逐渐增高(P＜0.05).结论p53基因杂合性缺失是食管癌发生、发展过程中的重要分子学事件.
|
| 关 键 词： | 食管肿瘤 p53基因 杂合性缺失 |
| 修稿时间： | 2003年3月31日 |
Detecting of p53 gene heterozygosity loss in esophageal carcinoma tissues |
| |
| LI Weijiang ,DUAN Jinxia.Detecting of p53 gene heterozygosity loss in esophageal carcinoma tissues[J].Journal of Zhengzhou University: Med Sci,2004,39(3):499-501. |
| |
| Authors: | LI Weijiang DUAN Jinxia |
| |
| Institution: | LI Weijiang 1),DUAN Jinxia 2) 1)Department of Internal Medicine,General Hospital of Zhongyuan Oilfields,Fanxian 457001 2)Department of Laboratory Center,Central Hospital of Nanyang City,Nangyang 473000 |
| |
| Abstract: | Aim: To reveal the relationship between loss of heterozygosity(LOH) of p53 gene and the carcinogenesis and progression of esophageal carcinoma. Methods: Thirty specimens of esophageal carcinoma, 30 para carcinoma tissues, and 30 normal esophageal epithelial tissues were examined for LOH of p53 gene by fluorescence in situ hybridization(FISH).Results:LOH of p53 gene positive rate was observed in esophageal carcinoma cells (63.3%,19/30), which was significantly higher than that(16.7%,5/30) in para carcinoma and that(0) in normal esophageal epithelial tissues( P < 0.05). Conclusion: LOH of p53 gene plays an important role in the carcinogenesis and progression of esophageal carcinoma. |
| |
| Keywords: | esophageal neoplasm p53 gene loss of heterozygosity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
