| 海南树仔菜急性毒性及遗传毒性研究 |
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| 引用本文： | 郑定仙,黄业宇,林卫华,冯丁山,吴爱琴,张晓昕,王湛.海南树仔菜急性毒性及遗传毒性研究[J].中国热带医学,2009,9(10):1969-1969,1983. |
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| 作者姓名： | 郑定仙 黄业宇 林卫华 冯丁山 吴爱琴 张晓昕 王湛 |
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| 作者单位： | 海南省疾病预防控制中心,海南,海口,570203 |
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| 摘 要： | 目的对海南树仔菜进行急性毒性及遗传毒性研究。方法采用急性毒性试验、Ames试验、小鼠骨髓细胞微核试验和小鼠精子畸形试验。结果树仔菜干粉雄雌性小鼠经口最大耐受剂量（MTD）〉10．0Ckg体重；Ames试验、小鼠骨髓细胞微核试验和小鼠精子畸形试验三项遗传毒性试验结果均为阴性。结论海南树仔菜急性毒性分级属实际无毒级、在本研究剂量范围内未见明显遗传毒性作用。
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| 关 键 词： | 海南树仔菜 急性毒性 遗传毒性 |
Assessment of acute toxicity and genotoxicity of Sauropus androgynus planted in Hainan |
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| Institution: | ZHENG Ding-yaan, HUANG Ye-yu, LIN Wei-hua, et al. (Hainan Provincial Center for Disease Control and Prevention, Haikou 570203, Hainan, P. R. China) |
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| Abstract: | Objective To evaluate toxicity and genotoxicity of Sauropus androgyrus planted in Hainan. Methods Acute toxicity test,Ames test,micronucieus test,sperm shape abnomality test were performed. Results The oral MTD in male or female mice was higher than 10.0g/kg.bw.Ames test,micronecleus test and sperm shape abnormality were negative. Conclusion Sauropus androgynus in Hainan has no acute toxicity and no genotoxicity. |
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| Keywords: | Sauropus androgynus Acute toxicity Genotoxie toxicity |
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