联合测定a-干扰素和癌胚抗原在结核性胸腔积液和恶性胸腔积液鉴别诊断中的价值

目的探讨a-干扰素（IFN-a）、癌胚抗原（CEA）联合检测在结核性胸腔积液和恶性胸腔积液鉴别诊断中的价值。方法以60例胸腔积液患者为研究对象,其中结核性胸腔积液31例,恶性胸腔积液29例,应用ELISA法检测IFN-a和CEA的浓度。结果结核性胸腔积液IFN-a含量高于恶性胸腔积液组,差异有显著性（P〈0.01）：恶性胸腔积液组CEA含量高于结核性胸腔积液组,差异有显著性（P〈0.01）。IFN-a对结核性胸腔积液诊断的敏感性和特异性分别为96.8%、93.1%;CEA对恶性胸腔积液诊断的敏感性和特异性分别为86.2%、93.5%;IFN-a和CEA联合检测对结核性胸腔积液诊断的敏感性和特异性分别为100%、96.6%。结论IFN-a和CEA可以作为临床上鉴别结核性胸腔积液和恶性胸腔积液的有效指标,联合检测对结核性胸腔积液和恶性胸腔积液的鉴别诊断的意义更大。

Diagnosis value of a-interferon determination combined with carcinoembryonic antigen in tuberculous pleural effusion and malignant pleural effusion

Objective To explore the a-interferon(IFN-a), carcinoembryonic antigen (CEA) in the combined detection of tuberculous pleural effusion and malignant pleural effusion diagnosis. Methods 60 cases of pleural effusion in patients for the study, in which tuberculosis pleural effusion in 31 cases, 29 cases of malignant pleural effusion, the application of ELISA assay and IFN-a concentration of CEA. Results the content of IFN-a in tuberculosis pleural effusion were higher than those group of malignant pleural effusion, there was a significant difference (P<0.01): malignant pleural effusion group were higher than those of CEA tuberculosis pleural effusion group, there was a significant difference (P < 0.01). IFN-a on the diagnosis of tuberculosis pleural effusion of the sensitivity and specificity were 96.80%, 93.1%; CEA for the diagnosis of malignant pleural effusion of the sensitivity and specificity were 86.2%, 93.5%; IFN-a and CEA joint detection of tuberculosis pleural effusion diagnosis sensitivity and specificity were 100%, 96.6%. Conclusions IFN-a and CEA can be used as identification of clinically tuberculosis pleural effusion and malignant pleural effusion, the joint detection of tuberculosis pleural effusion and malignant pleural effusion of the significance of the differential diagnosis are more significant.